Results 31 to 40 of about 1,913 (240)
Entreciencias: Diálogos en la Sociedad del Conocimiento, 2017 Las primeras solicitudes de protección de las invenciones biotecnológicas por medio de patente encontraron resistencia en las oficinas de patentes y en los tribunales.
Carlos Ernesto Arcudia Hernández
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Revista Española de Documentación Científica, 2008 La Biblioteca de la Escuela Politécnica Superior de la Universidad Carlos III de Madrid abre un nuevo servicio de información sobre patentes, tomando como base el depósito por parte de la Oficina Española de Patentes y Marcas (OEPM) de una amplia ...
Julio Macías González
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Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Las patentes farmacéuticas en México: de la prohibición a su potenciación por el T-MEC
La Propiedad Inmaterial, 2021 La concesión de patentes farmacéuticas en México ha sido parte del proceso de apertura comercial. De forma paralela a la incorporación de nuestro país a los acuerdos de libre comercio, se permitió la patentabilidad de invenciones farmacéuticas, dar ...
Carlos Ernesto Arcudia Hernández +1 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
RDBCI: Revista Digital de Biblioteconomia e Ciência da Informação, 2010 Acredita-se que as patentes são pouco exploradas como documentos fornecedores de informações; tanto por empresas, quanto por instituições de pesquisa, universidades, etc.
Juliana de Paula Ravaschio +2 more
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