Results 211 to 220 of about 629,369 (262)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The impact of patent activity on idiosyncratic volatility in U.S. pharmaceutical companies. [PDF]

PLoS One
Atilgan E, Türkmen Ceylan FB, Doruk ÖT, Ertuğrul HM, Barak AY.   +4 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

TB vaccine development: monitoring international patent filings to anticipate access challenges. [PDF]

Front Public Health
Pignataro MF, Scopel CT, Bacigalupo ML, Frick M, Kondratyuk S, Chaves GC.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Predatory Medical Journals in Patent Literature: A Hidden Threat. [PDF]

Adv Pharm Bull
Hegedűs M, Dadkhah M, Dávid LD.
europepmc   +1 more source

Correction: Recent advances in MOF-based single-atom photocatalysts for CO₂ to solar fuel conversion under sunlight irradiation. [PDF]

Chem Sci
Majeed A, Duong MK, Nguyen VD, Do TO.
europepmc   +1 more source

PROTAC-PatentDB: A PROTAC Patent Compound Dataset. [PDF]

Sci Data
Cai H, Yao G, Shi Y, Zhang T, Hu Y.
europepmc   +1 more source

Public values in public R&D through natural language processing. [PDF]

Sci Rep
Jang H, Roh T, Yoon B.
europepmc   +1 more source