Results 131 to 140 of about 226,140 (260)

Patents, appropriate technology, and North-South trade [PDF]

open access: yes
In this paper, the authors discuss the possibility that the North and South may have differing technological needs. Just as the North would like to develop drugs against cancer and heart disease, and the South drugs against tropical disease, so the North'
Rodrik, Dani, Diwan, Ishac
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Linking science to technology: using bibliographic references in patents to build linkage schemes. [PDF]

open access: yes
In this paper, we develop and discuss a method to design a linkage scheme that links the systems of science and technology through the use of patent citation data.
Luwel, M   +5 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

La llengua i les patents

open access: yesTerminàlia, 2017
Mireia Curell i Aguilà
doaj  

A bibliometric analysis of the top 100 most-cited shoulder arthroscopy patents. [PDF]

open access: yesJSES Rev Rep Tech
Bhardwaj N   +8 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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