Results 191 to 200 of about 473,566 (254)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

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The effect of energy patents on China's carbon emissions: Evidence from the STIRPAT model

Technological Forecasting and Social Change, 2021
Junbing Huang, Xinghao Li
exaly   +2 more sources

Patents involving nanocellulose: Analysis of their evolution since 2010

Carbohydrate Polymers, 2020
During the last two decades cellulosic nanomaterials have been the subject of much research around the world. Moreover, in the last few years, increasing industrial interest on the field enabled the setting-up of the first facilities producing commercial
Ema Cavallo, Maria Laura Foresti
exaly   +2 more sources

Solid lipid nanoparticles: a review on recent perspectives and patents

Expert Opinion on Therapeutic Patents, 2020
Introduction: Solid lipid nanoparticles (SLNs) are solid core lipid nanocarriers, which can hold both hydrophilic and hydrophobic drugs. They can be made up of biocompatible ingredients and therefore are one of the preferred choices for drug delivery ...
Rishi Paliwal, S. Paliwal, Rameshroo Kenwat, B. Kurmi, M. Sahu   +4 more
semanticscholar   +1 more source

Role of Nanotechnology in Electronics: A Review of Recent Developments and Patents.

Recent Patents on Nanotechnology, 2021
BACKGROUND Nanotechnology assures to be the base of the upcoming industrial revolution. The role that nanotechnology plays in electronic devices became a question of concern among the researchers when nanotechnology started to be the focal point of ...
Payal, P. Pandey
semanticscholar   +1 more source

A review on the field patents and recent developments over the application of metal organic frameworks (MOFs) in supercapacitors

, 2020
Global energy demand and the seriousness in sustainable energy obligations along with a large amount of CO2 emission and rapid depletion of fossil fuels have diligently persuaded the researchers to promote eco-benign energy storage systems with high ...
F. B. Ajdari, E. Kowsari, M. N. Shahrak, A. Ehsani, Z. Kiaei, Hoda Torkzaban, Mahshid Ershadi, Saeideh Kholghi Eshkalak, V. Haddadi‐Asl, A. Chinnappan, S. Ramakrishna   +10 more
semanticscholar   +1 more source

The drivers of economic complexity: International evidence from financial development and patents

, 2020
This study investigates the impacts of patents and financial development on economic complexity in a sample of 52 economies (including 32 high-income economies (HIEs) and 20 middle-income economies (MIEs)).
C. Nguyen, C. Schinckus, Thanh Dinh Su
semanticscholar   +1 more source