Results 91 to 100 of about 147,683 (344)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Wave and Tidal Energy: A Patent Landscape Study

Journal of Marine Science and Engineering
Wave and tidal energy, recognized as vital renewable resources, harness the ocean’s kinetic and potential power. This study aims to provide an in-depth patent analysis of the technological landscape within these sectors. We applied a dual approach: first,
Mohamadreza Pazhouhan, Amin Karimi Mazraeshahi, Mohammad Jahanbakht, Kourosh Rezanejad, Mohammad Hossein Rohban   +4 more
doaj   +1 more source

Human Rights and Intellectual Property: Mapping the Global Interface [PDF]

, 2010
Human Rights and Intellectual Property: Mapping the Global Interface explores the intersections between intellectual property and human rights law and policy.
Austin, Graeme W., Helfer, Laurence R.
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Intellectual Property Rights and Public Health: A Critical Examination of the AfCFTA Framework

The Journal of Medicine, Law & Public Health
Background: The African Continental Free Trade Area Intellectual Property Rights Protocol (AfCFTA IP Protocol) incorporates several public health-related provisions designed to enhance health across the free trade area.
Chimdessa Tsega
doaj  

A Patent Analysis to Identify Emergent Topics and Convergence Fields: A Case Study of Chitosan [PDF]

, 2021
Worasak Klongthong, Veera Muangsin, Chupun Gowanit, Nongnuj Muangsin   +3 more
openalex   +1 more source

TECHNICAL AND PATENT PERSPECTIVE ON FILM FORMING TOPICAL SPRAYS

International Journal of Pharmacy and Pharmaceutical Sciences
Film-forming systems were a viable option for topical and transdermal medication administration in the present study. Medication administered via the skin serves two purposes: topical treatment of skin disorders and transdermal drug absorption into the circulation.
M. H. DEHGHAN, SAILI P. RAJPUT
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Technical Progress Analysis Using a Dynamic Topic Model for Technical Terms to Revise Patent Classification Codes [PDF]

, 2020
Mana Iwata, Yoshiro Matsuda, Yoshimasa Utsumi, Yoshitoshi Tanaka, Kazuhide Nakata   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source