Results 91 to 100 of about 54,686,464 (254)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Wave and Tidal Energy: A Patent Landscape Study
Journal of Marine Science and EngineeringWave and tidal energy, recognized as vital renewable resources, harness the ocean’s kinetic and potential power. This study aims to provide an in-depth patent analysis of the technological landscape within these sectors. We applied a dual approach: first,
Mohamadreza Pazhouhan +4 more
doaj +1 more source
Refining the Measurement of Topic Similarities Through Bibliographic Coupling and LDA
IEEE Access, 2019 Generally, two topics with vastly different terminology probably indicate different implied concepts. However, these topics themselves might share common references (bibliographic coupling), which suggest the underlying joint concept.
Omer Hanif +3 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Applicant and Examiner Citations in US Patents: An Overview and Analysis [PDF]
Researchers studying innovation increasingly use indicators based on patent citations. However, it is well known that not all citations originate from applicants--patent examiners contribute to citations listed in issued patents--and that this could ...
Michelle Gittelman +2 more
core
International Maritime Transport and Logistic JournalThe context of the topic is to present briefly the importance of patents in the context of technological innovation and the role of artificial intelligence in generating inventions.
Angela Repanovici, Gabriela Ivanus
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Can Post-Grant Reviews Improve Patent System Design? A Twin Study of US and European Patents [PDF]
This paper assesses the impact of adopting a post-grant review institution in the US patent system by comparing the “opposition careers†of European Patent Office (EPO) equivalents of litigated US patents to those of a control group of EPO patents. We
Harhoff, Dietmar, Graham, Stuart J.H.
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source