Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Patents from the Academe: A Methodology Research for the Analysis of University Patents and Preliminary Findings for Turkey [PDF]
University patenting has been drawing attention of researchers studying university-industry relations, technology transfer mechanisms, changing research motives of the academe and consequences on their scientific performance. This study aims to develop a
Serkan Atmaca
core
Research on smart ship technology topic mining and impact quantification based on BERTopic and contrimetric. [PDF]
Sci RepJi D, Yang Y, Guo J.
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Structural characteristics and evolutionary trajectories of knowledge recombination in the field of AI-driven drug discovery. [PDF]
Sci RepXiao J, Li T, Luan Y, Chen X.
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PATENTS, R&D AND LAG EFFECTS: EVIDENCE FROM FLEXIBLE METHODS FOR COUNT PANEL DATA ON MANUFACTURING FIRMS [PDF]
Hausman, Hall and Griliches (1984) and Hall, Griliches and Hausman (1986) investigated whether there was a lag in the patent-R&D relationship for the U.S. manufacturing sector using 1970¿s data.
Fidel Pérez Sebastián, Shiferaw Gurmu
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Patent license prediction using deep survival analysis: A comparative study. [PDF]
PLoS OneArai T, Inoue H.
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Scientific and Technological Developments in Brain-Computer Interfaces: Dual Bibliometric Analysis of Articles and Patents. [PDF]
JMIR Rehabil Assist TechnolWang J, Yuan Y, Xu H, Luan G.
europepmc +1 more source