Results 131 to 140 of about 54,686,464 (254)
Evaluating patent portfolios by means of multicriteria analysis
Revista de Contabilidad: Spanish Accounting Review, 2011 Valuation of intangible assets is a complex topic where traditional methodologies are not always successful. Nevertheless, intangible assets, like patents, have become of great importance to companies, as their value is considered to be relevant economic
Xiaolu Wang +3 more
doaj
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Patents, Thickets, and the Financing of Early-Stage Firms: Evidence from the Software Industry [PDF]
The impact of stronger intellectual property rights in the software industry is controversial. One means by which patents can affect technical change, industry dynamics, and ultimately welfare, is through their role in stimulating or stifling entry by ...
Megan MacGarvie, Iain M. Cockburn
core
The market value of blocking patent citations [PDF]
There is a growing literature that aims at assessing the private value of knowledge assets and patents. It has been shown that patents and their quality as measured by citations received by future patents contribute significantly to the market value of ...
Czarnitzki, Dirk +2 more
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The relative effectiveness of patents and secrecy for appropriation. [PDF]
Appropriation;Innovation surveys;Patents;Secrecy;
Arundel, Anthony
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Benchmarking of patents: An application of GAM methodology [PDF]
The present article reexamines some of the issues regarding the benchmarking of patents using the NBER data base on U.S. patents by generalizing a parametric citation model and by estimating it using GAM methodology.
Orbe Mandaluniz, Susan +1 more
core
Who\'s Who in Patents. A Bayesian approach [PDF]
This paper proposes a bayesian methodology to treat the who’s who problem arising in individual level data sets such as patent data. We assess the usefullness of this methodology on the set of all French inventors appearing on EPO applications from 1978 ...
Nicolas CARAYOL (GREThA UMR CNRS 5113) +1 more
core +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source