Results 121 to 130 of about 157,262 (340)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

The determinants of scientific research agenda: Why do academic inventors choose to perform patentable versus non-patentable research? [PDF]

This paper explores the determinants of scientific research agenda. By using an original dataset that includes extensive information about 269 French academic inventors, we analyze why scientists choose to perform patentable versus non-patentable ...
Hussler Caroline, Pénin Julien
core  

Are Universities Patent Trolls? [PDF]

, 2008
Hold-up is a primary component of patent litigation and patent licensing today. Universities are engaged in an unprecedented surge in patenting. At the confluence of these seemingly unrelated developments is a growing frustration on the part of ...
Lemley, Mark A.
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Measurement and Spatiotemporal Evolution Characteristics of Artificial Intelligence Invention Patents in Guangdong Based on the BERT Large Language Model

Redai dili
Artificial intelligence (AI) has emerged as a key driver of high-quality regional development by reshaping innovation systems, industrial structures, and spatial economic dynamics.
Chen Yijia, Tan Juntao, Yang Ruilin
doaj   +1 more source

What makes a gatekeeper? Insights from the Finnish nano-community [PDF]

In the process of transferring scientific knowledge to industry the role of individual academics has received less attention than the other actors in this process.
Tuomo Nikulainen
core  

Worldwide Research Trends on Wheat and Barley: A Bibliometric Comparative Analysis [PDF]

, 2019
Grain cereals such as wheat, barley, rice, and maize are the nutritional basis of humans and animals worldwide. Thus, these crop plants are essential in terms of global food security.
Benavente Barzana, María Elena, Giménez Caminero, Estela, Giraldo Carbajo, Patricia, Manzano Agugliaro, Francisco   +3 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Drug Repositioning in the Mirror of Patenting: Surveying and Mining Uncharted Territory

Frontiers in Pharmacology, 2017
Hermann A. M. Mucke
doaj   +1 more source