Results 221 to 230 of about 54,686,464 (254)

Development and Validation of a Computational Histology Artificial Intelligence-Powered Biomarker in Metastatic Hormone-Sensitive Prostate Cancer on Randomized Phase III Trials. [PDF]

JCO Precis Oncol
Sweeney CJ, Krishna V, Krishna V, Neema A, Tarsode A, Subhash VV, Horvath LG, Kench JG, Stockler MR, Yip S, Thomas H, Swami U, Zhang H, Sonawane S, Abuzeid WM, Nimgaonkar V, Tiu E, Watson D, Kiedrowski L, Royce TJ, Yang DD, Tran PT, Ryan CJ, Nguyen PL, Morgans AK, Joshi A, Agarwal N, Davis ID.   +27 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Identification and Evolution of Core Technologies in the Chip Field Based on Patent Networks. [PDF]

Entropy (Basel)
Wang Y, Chen R, Chen J.
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

An evaluation of the US public-private Combating Antibiotic-Resistant Bacteria Accelerator (CARB-X) initiative. [PDF]

Health Aff Sch
Conti RM, Alexander M, Evans EJ.
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Entropy-Based Patent Valuation: Decoding "Costly Signals" in the Food Industry via a Robust Entropy-TOPSIS Framework. [PDF]

Entropy (Basel)
Li X, Liu W, Liang X, Zhou A.
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Refined Continuous Risk Index for Accurately Predicting Outcomes of Patients With Chronic Lymphocytic Leukemia After Limited-Duration Therapy. [PDF]

J Clin Oncol
Al-Sawaf O, Zhang C, Esfahani MS, Liu CL, Robrecht S, Tausch E, Schilhabel A, Ritgen M, Schneider C, Peifer M, Fürstenau M, Niemann CU, Kater AP, Seymour JF, Chyla B, Jiang Y, Eichhorst B, Stilgenbauer S, Hallek M, Alizadeh AA, Kurtz DM, Fischer K.   +21 more
europepmc   +1 more source

AI-assisted interpretation of Markush structures in pharmaceutical patents: a review of emerging tools, datasets, and challenges. [PDF]

J Cheminform
Hayes JMU, Olawode EO, Andy A, Ameyaw EE.   +3 more
europepmc   +1 more source