Results 181 to 190 of about 29,236 (313)

MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder characterized by progressive spasticity and lower limb weakness. The most common forms of autosomal dominant HSP are caused by pathogenic variants in SPAST (SPG4 or HSP‐SPAST), ATL1 (SPG3A or HSP‐ATL1), and REEP1 (SPG31 or HSP‐REEP1).
Ce Kang, Rajasumi Rajalingam, Zachary Walls, Jana Huang, Christine Sun, Laura I. Rudaks, Dennis Yeow, Ashar Rasheed, Jenny W. Zhang, Moath Hamed, Marianthi Breza, Susen Schaake, Chetan Vekhande, Jason Massa, Robyn E. Massa, Aakash Shetty, Carolyn M. Sue, Franca Cambi, Oksana Suchowersky, Franca Vulinovic, Sonja Petkovic, Christine Klein, Katja Lohmann, Connie Marras, Kishore R. Kumar   +24 more
wiley   +1 more source

Mating-dependent lifespan cost of sterol depletion in male <i>Drosophila melanogaster</i>. [PDF]

Proc Natl Acad Sci U S A
McCracken AW, White N, Tanianis-Hughes J, Rosca E, Gill T, McKinney L, Simpson SJ, Reinhardt K, Brankatschk M, Piper MDW, Morimoto J, Wigby S.   +11 more
europepmc   +1 more source

Real‐World Safety and Effectiveness of Glatiramer Acetate in Patients With Multiple Sclerosis: Final Results of Post‐Marketing Surveillance in Japan

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Background Glatiramer acetate is an injectable disease‐modifying therapy indicated for multiple sclerosis (MS). Aim To evaluate the real‐world safety and effectiveness of glatiramer acetate for MS in Japan. Methods A prospective, multicenter, observational, all‐case post‐marketing survey was conducted in Japan between November 2015 and March ...
Masaaki Niino, Eriko Hayashi, Mai Itani, Jun‐ichi Kira   +3 more
wiley   +1 more source

Arguments and Analogies: Do Children Have a Right to Know Their Genetic Origins? [PDF]

Hastings Cent Rep
Charles S.
europepmc   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, EarlyView.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

L’essence de l’engagement paternel chez des pères agriculteurs résidant en région éloignée : une étude phénoménologique

Enfances, Familles, Générations
Research Framework: Scientific literature shows that farmers are particularly at risk of experiencing mental health problems. However, many farmers mention that their role as fathers is directly related to their state of health.
Gabriel Gingras-Lacroix, Oscar Labra
doaj  

Interaction Between Genetic Risk and Parental Feeding Practices in the Prediction of Overweight Across Adolescence

Obesity, EarlyView.
ABSTRACT Objective We examined whether genetic risk for higher BMI, parental feeding practices (restriction, pressure to eat, and monitoring), and their interactions were associated with overweight trajectories during adolescence. Methods Data came from 5568 participants aged 10–18 in the Twins' Early Development Study who had at least one measurement ...
Marthe de Roo, Tina Kretschmer, Clare Llewellyn, Bonamy R. Oliver, Catharina A. Hartman   +4 more
wiley   +1 more source

Subtle discrimination of fathers in relation to leave-taking: a comparative study of Slovakia and Poland. [PDF]

Front Sociol
Dančíková Z, Muter M.
europepmc   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source

Changes in PSA-Based Early Detection of Prostate Cancer over a 12-Year Period: Findings from the German KABOT Study. [PDF]

Healthcare (Basel)
Braun KP, Vogel T, May M, Gilfrich C, Herrmann M, Kravchuk AP, Maurer J, Wolff I.   +7 more
europepmc   +1 more source