Results 21 to 30 of about 761,024 (258)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Test the effectiveness of some medications and vitamin D3 used against COVID-19 on Gram-positive and Gram-negative bacteria isolated from people infected with the Coronavirus

مجلة علوم ذي قار
The COVID-19 pandemic has led to a search for effective pharmaceuticals and vitamins to combat the virus. These therapies have antiviral capabilities and can affect both gram-negative and gram-positive bacteria.
Amal F. AL-Gorani, Hanan Saadon, Ahmed. K. Ajeel, Noor abd alkhudhur salman, Aya Talib jawad, Hussein Adnan Obaid, Hasan Mohsen Koti   +6 more
doaj   +1 more source

Design and methods for a quasi-experimental pilot study to evaluate the impact of dual active ingredient insecticide-treated nets on malaria burden in five regions in sub-Saharan Africa

Malaria Journal, 2022
Background Vector control tools have contributed significantly to a reduction in malaria burden since 2000, primarily through insecticidal-treated bed nets (ITNs) and indoor residual spraying.
Adama Gansané, Baltazar Candrinho, Aimable Mbituyumuremyi, Perpetua Uhomoibhi, Sagnon NFalé, Audu Bala Mohammed, Wamdaogo Moussa Guelbeogo, Antoine Sanou, David Kangoye, Siaka Debe, Moubassira Kagone, Emmanuel Hakizimana, Aline Uwimana, Albert Tuyishime, Chantal M. Ingabire, Joseph H. Singirankabo, Hannah Koenker, Dulcisaria Marrenjo, Ana Paula Abilio, Crizologo Salvador, Binete Savaio, Okefu Oyale Okoko, Ibrahim Maikore, Emmanuel Obi, Samson Taiwo Awolola, Adedapo Adeogun, Dele Babarinde, Onoja Ali, Federica Guglielmo, Joshua Yukich, Sara Scates, Ellie Sherrard-Smith, Thomas Churcher, Christen Fornadel, Jenny Shannon, Nami Kawakyu, Emily Beylerian, Peder Digre, Kenzie Tynuv, Christelle Gogue, Julia Mwesigwa, Joseph Wagman, Monsuru Adeleke, Ande Taiwo Adeolu, Molly Robertson   +44 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Implementation of a structured emergency nursing framework results in significant cost benefit

BMC Health Services Research, 2021
Background Patients are at risk of deterioration on discharge from an emergency department (ED) to a ward, particularly in the first 72 h. The implementation of a structured emergency nursing framework (HIRAID) in regional New South Wales (NSW ...
Kate Curtis, Prabhu Sivabalan, David S. Bedford, Julie Considine, Alfa D’Amato, Nada Shepherd, Margaret Fry, Belinda Munroe, Ramon Z. Shaban   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Three-year trends in malaria transmission parameters under deployment of Interceptor®G1, Interceptor®G2 and PermaNet®3.0 insecticide-treated bed nets in South-Western Burkina Faso

Malaria Journal
Background In South-Western Burkina Faso, where malaria remains highly endemic, the widespread resistance of Anopheles mosquitoes to pyrethroid is reducing the effectiveness of insecticide-treated nets (ITNs).
Madou Tapsoba, Wamdaogo Moussa Guelbeogo, Antoine Sanou, Soumanaba Zongo, Christelle Gogue, Siaka Debe, Kyra Arnett, Kelly Davis, Jenny Shannon, Peder Digre, Julia Mwesigwa, Kenzie Tynuv, Christen Fornadel, Sagnon N’Falé, Molly Robertson, Joseph D. Challenger, Gauthier Tougri, Adama Gansané, Hilary Ranson, Gnankiné Olivier, Joseph Wagman   +20 more
doaj   +1 more source

Correlations between soil attributes and the occurrence of nematodes and grain yield in an off-season maize crop in Mato Grosso do Sul

Bioscience Journal, 2020
Systems of soil cultivation and use directly influence crop yield by interfering with the soil chemical, physical, and biological attributes. This study aimed to evaluate the correlation between maize grain yield, soil chemical and biological attributes,
Valquiria Krolikowski, Gessi Ceccon, Katiane Secco Castro, Paulo Eduardo Teodoro   +3 more
doaj  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source