Results 21 to 30 of about 22,807,054 (202)
مجلة علوم ذي قارThe COVID-19 pandemic has led to a search for effective pharmaceuticals and vitamins to combat the virus. These therapies have antiviral capabilities and can affect both gram-negative and gram-positive bacteria.
Amal F. AL-Gorani +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Basic Study on Anomaly Diagnosis for Infrastructure Using Operational Transfer Path Analysis [PDF]
, 2015 This paper describes a new health monitoring method using operational transfer path analysis for operating machine and infrastructure. At first, vibrational characteristics of the operational transfer path analysis to a two-beam structure consists of ...
クロダ, カツヒコ, 黒田, 勝彦
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Malaria JournalBackground In South-Western Burkina Faso, where malaria remains highly endemic, the widespread resistance of Anopheles mosquitoes to pyrethroid is reducing the effectiveness of insecticide-treated nets (ITNs).
Madou Tapsoba +20 more
doaj +1 more source
Predictive Models of Adult Distance Learners' Academic Performance: Comparative Analysis of Two Regression-based Models of Path Analysis [PDF]
, 2011 Using two regression-based models, this study looked into factors that explain academic performance of adult distance learners. The efficiency and applicability of linear regression and logit regression procedures as statistical models for path analysis ...
Quimbo, Maria Ana T.
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Parasites & VectorsBackground The introduction of next-generation insecticide-treated nets (ITNs) in Burkina Faso aims to mitigate pyrethroid resistance in malaria vectors.
Madou Tapsoba +20 more
doaj +1 more source
BMJ Global HealthEstimates of malaria prevalence and intervention coverage in Africa are primarily based on nationally representative household (HH) surveys. However, the expense and infrequency limit the utility of HH surveys for operational action by malaria programmes.
+46 more
doaj +1 more source