Results 31 to 40 of about 713,475 (259)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mathematical modeling for analyzing mass drug administration operational factors for efficient malaria incidence reduction in southern Senegal

Infectious Disease Modelling
Mass drug administration (MDA) has emerged as a promising strategy for reducing malaria incidence in many African countries. A pilot study of MDA in the Tambacounda health district in southeastern Senegal had a significant impact on reducing the malaria ...
Khady Ndiaye, El Hadji S. Diop, Hannah C. Slater, Mor A. Loum, Jean-L.A. Ndiaye, Ibrahima Diallo, Medoune NDiop, Standeur N. Kaly   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Genetic Variability Induced by Gamma Rays and Preliminary Results of Low-Cost TILLING on M2 Generation of Chickpea (Cicer arietinum L.)

Frontiers in Plant Science, 2018
In order to increase genetic variability for chickpea improvement, the Kabuli genotype, variety Ghab4, was treated with 280 Grays of gamma rays (Cobalt 60). Field characterization began with the M2 generation.
Wahiba Amri-Tiliouine, Wahiba Amri-Tiliouine, Meriem Laouar, Aissa Abdelguerfi, Joanna Jankowicz-Cieslak, Ljupcho Jankuloski, Bradley J. Till, Bradley J. Till   +7 more
doaj   +1 more source

DAIRY PRODUCTION OF ‘SAANEN’ GOATS BASED ON METEOROLOGICAL VARIABLES AND FUTURE CLIMATE SCENARIOS [PDF]

Engenharia Agrícola, 2017
This study aimed to modeling and bioclimatic zoning of ‘Saanen’ goat milk production in northeastern Brazil. Data were obtained from a 14-year dairy control program for 246 ‘Saanen’ goat matrices.
Izaac D. Pequeno, Silvia H. N. Turco, Thieres G. F. da Silva, Olivardo Facó   +3 more
doaj   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

PATH ANALYSIS OF FACTORS INFLUENCING CASHLESS SOCIETY DEVELOPMENT USING BOOTSTRAP RESAMPLING

Barekeng
Path analysis can be applied to various fields, one of which is the field of banking economics. This study is aimed to examine what factors significantly affect the development of cashless society both directly and indirectly.
Dea Saraswati Pramaningrum, Adji Achmad Rinaldo Fernandes, Atiek Iriany, Solimun Solimun   +3 more
doaj   +1 more source

Screening of Superior Phenotypic and Physicochemical Indices of Equisetum arvense L. Using Path Analysis [PDF]

Agrotechniques in Industrial Crops
Horsetail (Equisetum arvense) has gained prominence in the herbal products industry, particularly for nail and hair-strengthening formulations, owing to its high silicon (Si) content.
Saiedeh Peyghambarzadeh, Teimour Babaeinejad, Javad Hadian, Allahyar Fallah, Navid Ghanavati   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source