Results 41 to 50 of about 1,139,677 (338)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

As a Chinese researcher in Belgium: Path dependence or path-breaking?

Belgeo
Extra-regional linkages contribute to innovation. However, detailed thoughts of innovators are missing in the literature. A question arises: how does a newly established extra-regional linkage affect knowledge production?
Fan Xiao
doaj   +1 more source

Compaction and dilation rate dependence of stresses in gas-fluidized beds

, 2006
A particle dynamics-based hybrid model, consisting of monodisperse spherical solid particles and volume-averaged gas hydrodynamics, is used to study traveling planar waves (one-dimensional traveling waves) of voids formed in gas-fluidized beds of narrow ...
Crowe C. T., Davidson J. F., Derksen J., Gidaspow D., I. G. Kevrekidis, Israelachvili J. N., Jackson R., Jackson R., Moon S. J., Rowe P. N., Rumpf H., S. Sundaresan, Sung Joon Moon, Wen C. Y.   +13 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

The proton spin decomposition : path dependence and gauge symmetry

, 2013
We discuss the different types of decomposition of the proton spin. We stress that, despite their lack of uniqueness, the Chen et al. and Wakamatsu decompositions are perfectly measurable. We argue that a large part of the recent controversies boils down
Lorcé, C.
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Path Dependence of the Quark Nonlocal Condensate within the Instanton Model [PDF]

, 2004
Within the instanton liquid model, we study the dependence of the gauge invariant two--point quark correlator on the path used to perform the color parallel transport between two points in the Euclidean space.Comment: 4 pages, 5 ...
Dorokhov, A. E., Tomio, Lauro, Trevisan, L. A.   +2 more
core   +4 more sources

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Koncepcja uwarunkowań instytucjonalnych w nowej ekonomii instytucjonalnej

Zeszyty Naukowe Uniwersytetu Ekonomicznego w Krakowie, 2016
Rola instytucji w rozwoju i funkcjonowaniu całej gospodarki jest jednym z najciekawszych obszarów badawczych nowej ekonomii instytucjonalnej. W nurcie tym kryterium minimalizacji kosztów transakcyjnych zostało wykorzystane zarówno do analizy życia ...
Tomasz Tylec
doaj   +1 more source

Origins of the Differences in Political Systems of the Central Asian States: Threat Perception in the Perestroika Period

Международная аналитика, 2021
Using the “path-dependence” concept and D. Slater’s thesis on the consolidation of elites around national threats, the author examines the factors infl uencing the formation of diff erent authoritarian political systems in the Central Asian states.
Tomohiko Uyama
doaj   +1 more source