Results 21 to 30 of about 68,824 (259)

A New Space-Time Theory Unravels the Origins of Classical Mechanics for the Dirac Equation

open access: yesQuantum Reports
The Feynman path integral plays a central role in quantum mechanics, linking classical action to propagators and relating quantum electrodynamics (QED) to Feynman diagrams.
Wei Wen
doaj   +1 more source

Effective diffusion of a tracer in active bath: A path-integral approach

open access: yesNational Science Open
We investigate the effective diffusion of a tracer immersed in an active particle bath consisting of self-propelled particles. Utilising the Dean's method developed for the equilibrium bath and extending it to the nonequilibrium situation, we derive a ...
Feng Mengkai, Hou Zhonghuai
doaj   +1 more source

A Note On The First Class Approaches Of Massive P-Forms

open access: yesAnnals of West University of Timisoara: Physics, 2012
The problem of quantization of the massive p-forms is considered in the framework of the Batalin-Fradkin (BF) approach based on path integral. The quantization procedure relies on the path integral of a first-class system equivalent with the original ...
Sararu S. C., Udristioiu M. T.
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Nonlocal transformation of the internal quantum particle structure

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2016
The analysis of the integral wave equation, having path integral kernel, has resulted, that collapse phenomenon is based on the nonlocal transformation of the internal structure of a quantum particle, considering in the form of the matter fields ...
Alexey Yu Samarin
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Heat current in non-Markovian open systems

open access: yesNew Journal of Physics, 2023
We generalize time-evolving matrix product operators method to nonequilibrium quantum transport problems. The nonequilibrium current is obtained via numerical differentiation of the generating functional which is represented as a tensor network.
Ruofan Chen
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

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