Results 31 to 40 of about 226,666 (259)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Contact with nature for emotion regulation: the roles of nature connectedness and beauty engagement in urban young adults

Scientific Reports, 2023
Contact with nature has emotional benefits, but the psychological mechanism and potential moderator underlying the association between nature contact and emotion regulation remain unclear.
Xuan Gu, Hailin Zheng, Chi-Shing Tse
doaj   +1 more source

A Novel Tooth Modification Methodology for Improving the Load-Bearing Capacity of Non-Orthogonal Helical Face Gears

Machines, 2023
This study proposes a double-crown tooth surface modification technology that improves the load-carrying capacity of non-orthogonal helical tooth surface gears.
Chao Jia, Bingquan Li, Junhong Xu
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Modeling a HCR Gear with Variable Thickness of the Thin Hard Coating on the Tooth Surface for Fem Analysis

Journal of Mechanical Engineering
This work presents a computer model of HCR gear wheels with thin hard coatings of variable thickness. The coating thickness fluctuates along tooth depth due to limited technological space, particularly at the dedendum.
Protasov Roman, Danko Ján, Ustynenko Oleksandr, Soprunov Igor, Bondarenko Oleksij, Klochkov Illia, Marchenko Yevhenii   +6 more
doaj   +1 more source

Path Algorithms for Contact Sequence Temporal Graphs

Algorithms
This paper proposes a new time-respecting graph (TRG) representation for contact sequence temporal graphs. Our representation is more memory-efficient than previously proposed representations and has run-time advantages over the ordered sequence of edges (OSE) representation, which is faster than other known representations.
Sanaz Gheibi, Tania Banerjee, Sanjay Ranka, Sartaj Sahni   +3 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Solid‐State Diffusion and Intermetallic Phase Formation in Roll‐Bonded Mg–Zn Composites With Kirigami‐Patterned Inlay

Advanced Engineering Materials, EarlyView.
Mg–Zn composites with a thickness of 0.21 mm were fabricated using roll bonding of a kirigami‐patterned Mg alloy inlay within a Zn matrix. Thermal activation following this process led to the formation of tailored intermetallic structures, which provided the composite with enhanced flexural strength.
Yaroslav Frolov, Oleksandr Bobukh, Christian Klose, Florian Nürnberger, Hans Jürgen Maier   +4 more
wiley   +1 more source

Contact-Aware Path Planning for Autonomous Neuroendovascular Navigation

IEEE Robotics and Automation Letters
We propose a deterministic and time-efficient contact-aware path planner for neurovascular navigation. The algorithm leverages information from pre- and intra-operative images of the vessels to navigate pre-bent passive tools, by intelligently predicting and exploiting interactions with the anatomy.
Aabha Tamhankar, Ron Alterovitz, Ajit S. Puri, Giovanni Pittiglio   +3 more
openaire   +2 more sources