Results 41 to 50 of about 167,847,038 (291)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Contact with nature for emotion regulation: the roles of nature connectedness and beauty engagement in urban young adults

Scientific Reports, 2023
Contact with nature has emotional benefits, but the psychological mechanism and potential moderator underlying the association between nature contact and emotion regulation remain unclear.
Xuan Gu, Hailin Zheng, Chi-Shing Tse
doaj   +1 more source

A Novel Tooth Modification Methodology for Improving the Load-Bearing Capacity of Non-Orthogonal Helical Face Gears

Machines, 2023
This study proposes a double-crown tooth surface modification technology that improves the load-carrying capacity of non-orthogonal helical tooth surface gears.
Chao Jia, Bingquan Li, Junhong Xu
doaj   +1 more source

Path Algorithms for Contact Sequence Temporal Graphs

Algorithms
This paper proposes a new time-respecting graph (TRG) representation for contact sequence temporal graphs. Our representation is more memory-efficient than previously proposed representations and has run-time advantages over the ordered sequence of edges (OSE) representation, which is faster than other known representations.
Sanaz Gheibi, Tania Banerjee, Sanjay Ranka, Sartaj Sahni   +3 more
openaire   +2 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Attention to eye contact in the West and East: autonomic responses and evaluative ratings [PDF]

, 2013
Eye contact has a fundamental role in human social interaction. The special appearance of the human eye (i.e., white sclera contrasted with a coloured iris) implies the importance of detecting another person's face through eye contact.
Toshikazu Hasegawa, Kikuchi, Yukiko, Kikuchi, Y., Uibo Helen, Hasegawa Toshikazu, Uibo, H., Senju, Atsushi, Jari K Hietanen, Hietanen, J.K., Hasegawa, Toshikazu, Akechi, H., Hasegawa, T., Hietanen Jari K., Yukiko Kikuchi, Akechi Hironori, Kikuchi Yukiko, Uibo, Helen, Atsushi Senju, Helen Uibo, Hironori Akechi, Senju Atsushi, Akechi, Hironori, Hietanen, Jari, Mesoudi, A.   +23 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Modeling a HCR Gear with Variable Thickness of the Thin Hard Coating on the Tooth Surface for Fem Analysis

Journal of Mechanical Engineering
This work presents a computer model of HCR gear wheels with thin hard coatings of variable thickness. The coating thickness fluctuates along tooth depth due to limited technological space, particularly at the dedendum.
Protasov Roman, Danko Ján, Ustynenko Oleksandr, Soprunov Igor, Bondarenko Oleksij, Klochkov Illia, Marchenko Yevhenii   +6 more
doaj   +1 more source

Contact-Aware Path Planning for Autonomous Neuroendovascular Navigation

IEEE Robotics and Automation Letters
We propose a deterministic and time-efficient contact-aware path planner for neurovascular navigation. The algorithm leverages information from pre- and intra-operative images of the vessels to navigate pre-bent passive tools, by intelligently predicting and exploiting interactions with the anatomy.
Aabha Tamhankar, Ron Alterovitz, Ajit S. Puri, Giovanni Pittiglio   +3 more
openaire   +3 more sources