Results 31 to 40 of about 142,245 (260)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Journal of Marine Science and Engineering, 2023 The influence of the maritime environment such as water currents, water depth, and traffic separation rules should be considered when conducting ship path planning.
Rong Zhen +3 more
doaj +1 more source
Sensors, 2023 The search efficiency of a rapidly exploring random tree (RRT) can be improved by introducing a high-probability goal bias strategy. In the case of multiple complex obstacles, the high-probability goal bias strategy with a fixed step size will fall into ...
Youyu Liu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
An Adaptive Path Planning Algorithm for USV in Complex Waterways: SA-Bi-APF-RRT*
Journal of Marine Science and EngineeringIn recent years, the RRT* algorithm has been widely applied in industrial fields because of its asymptotic optimality. However, the traditional RRT* algorithm exhibits limitations in terms of convergence speed and quality of generated paths, and its path
Sixian Li +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Systems Science & Control EngineeringThe Vertical Takeoff and Landing Aircraft (VTOL) is capable of both low-speed hovering and high-speed flight. This paper proposes an autonomous motion planning and anti-wind disturbance control algorithm for the VTOL, implemented spatial and temporal ...
Liben Yang +3 more
doaj +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Discovering the backbone network with a novel designed ant colony algorithm
Tongxin xuebao, 2020 Forthe problem that in interactive network,the illegal and abnormal behaviors were becoming more hidden,moreover,the complex relation in real interactive network heightens the difficulty of detecting anomalous entities,an ant colony model was proposed ...
Fang LYU +3 more
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