Results 71 to 80 of about 1,634,389 (309)

Targeting Antibiotic Tolerance, Pathogen by Pathogen [PDF]

Cell, 2018
Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and underappreciated role in the disease burden of bacterial infections. Here, we take a pathogen-by-pathogen approach to illustrate the clinical significance of antibiotic tolerance and discuss how the ...
Meylan, Sylvain, Andrews, Ian W., Collins, James J.   +2 more
openaire   +4 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Non-systemic transmission of tick-borne diseases: a network approach [PDF]

, 2016
Tick-Borne diseases can be transmitted via non-systemic (NS) transmission. This occurs when tick gets the infection by co-feeding with infected ticks on the same host resulting in a direct pathogen transmission between the vectors, without infecting the ...
Bajardi, Paolo, Ferreri, Luca, Giacobini, Mario   +2 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Isolation, characterization and functional analysis of a bacteriophage targeting Culex pipiens pallens resistance-associated Aeromonas hydrophila

Parasites & Vectors
Background Culex pipiens pallens is a well-known mosquito vector for several diseases. Deltamethrin, a commonly used pyrethroid insecticide, has been frequently applied to manage adult Cx. pipiens pallens.
Jinze Li, Jiajia Du, Guangshuo Ding, Wenxing Zhang, Yinghui Zhou, Yidan Xu, Dan Zhou, Yan Sun, Xiaoqiu Liu, Bo Shen   +9 more
doaj   +1 more source

Loop-mediated isothermal amplification (LAMP) assays targeting 18S ribosomal RNA genes for identifying P. vivax and P. ovale species and mitochondrial DNA for detecting the genus Plasmodium

Parasites & Vectors, 2021
Background Loop-mediated isothermal amplification (LAMP) has been widely used to diagnose various infectious diseases. Malaria is a globally distributed infectious disease attributed to parasites in the genus Plasmodium. It is known that persons infected
Xi Chen, Jiaqi Zhang, Maohua Pan, Yucheng Qin, Hui Zhao, Pien Qin, Qi Yang, Xinxin Li, Weilin Zeng, Zheng Xiang, Mengxi Duan, Xiaosong Li, Xun Wang, Dominique Mazier, Yanmei Zhang, Wei Zhao, Benjamin M. Rosenthal, Yaming Huang, Zhaoqing Yang   +18 more
doaj   +1 more source

Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies. [PDF]

, 2020
Preventing bacterial infections from becoming the leading cause of death by the year 2050 requires the development of novel, infection-control strategies, building heavily on biomaterials science, including nanotechnology.
Busscher, Henk J., Frijlink, Hendrik W., Grainger, David W., Hinrichs, Wouter L.J., Jutte, Paul, Kates, Stephen, Liu, Jian, Liu, Jianfeng, Parvizi, Javad, Rotello, Vincent M., Schaer, Thomas P., Shi, Linqi, Shi, Rui, van der Mei, Henny C., van Kooten, Theo G., Williams, Dustin, Woudstra, Willem   +16 more
core   +2 more sources

Rotavirus Pathogenicity

Virology, 1996
The pathogenicity of rotaviruses depends on multiple viral and host factors. In this review the evidence for the involvement of a number of viral genes in the ability to cause disease is presented. Different genes are of importance in different rotavirus-host systems: there is no single pathogenicity factor.
Burke, B, Desselberger, U
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Caraway yellows virus, a novel nepovirus from Carum carvi

Virology Journal, 2019
A novel nepovirus was identified and characterised from caraway, and tentatively named caraway yellows virus (CawYV). Tubular structures with isomeric virus particles typical for nepoviruses were observed in infected tissues by electron microscopy.
Yahya Z. A. Gaafar, Katja R. Richert-Pöggeler, Angelika Sieg-Müller, Petra Lüddecke, Kerstin Herz, Jonas Hartrick, Christina Maaß, Roswitha Ulrich, Heiko Ziebell   +8 more
doaj   +1 more source