Results 211 to 220 of about 1,431,287 (296)

3D Bioprinted Human Synovium‐Cartilage Models Mimic Rheumatoid Arthritis Microenvironment and Recapitulate In Vivo Therapeutic Responses

Advanced Materials, EarlyView.
This study presents human in vitro rheumatoid arthritis models using chondrocytes recellularized type II collagen scaffold and 3D‐bioprinted Gelatin‐Matrigel hydrogels with fibroblast‐like synoviocytes, pro‐inflammatory macrophages, and protective barrier macrophages, closely recapitulating key rheumatoid arthritis pathological features.
Huiqun Zhou, Zhen Zhang, Yulei Mu, Liang Ma, Xu Hu, Bangheng Liu, Dong‐An Wang   +6 more
wiley   +1 more source

Regulatory dynamics of <i>IFI44L</i> in systemic lupus erythematosus: the interplay of type I interferon and c-Jun. [PDF]

Lupus Sci Med
Wang Y, Yang M, Ma H, Ma X, Huo Z, Ma Z, Dang J.   +6 more
europepmc   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications. [PDF]

MedComm (2020)
Zuo L, Liu Q, Ye D, Fan J, Wu L.
europepmc   +1 more source

Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease

, 2019
Ambra Del Grosso, Lucia Angella, Ilaria Tonazzini, Aldo Moscardini, Nadia Giordano, Matteo Caleo, Silvia Rocchiccioli, Marco Cecchini   +7 more
openalex   +2 more sources

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

Driver mutation-defined molecular landscapes of essential thrombocythemia. [PDF]

Blood Sci
Lorenzen AL, Huang G.
europepmc   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source