Results 211 to 220 of about 253,129 (246)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

open access: yesAdvanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge   +21 more
wiley   +1 more source

The role of immune cell signatures in the pathogenesis of ovarian-related diseases: a causal inference based on Mendelian randomization

open access: diamond
Yangguang Lu   +14 more
openalex   +1 more source
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Pathogenesis

Seminars in Reproductive Medicine, 1997
There are many hypotheses concerning the pathogenesis of endometriosis, though no single theory can explain all cases. It is likely that several mechanisms are involved. Early studies concentrated on the histogenesis of the endometriotic lesion. Recent evidence has implicated components of the immune system in the pathogenesis of endometriosis.
C A, Witz, R S, Schenken
openaire   +2 more sources

Malaria Pathogenesis

Science, 1994
Malaria is a disease caused by repeated cycles of growth of the parasite Plasmodium in the erythrocyte. Various cellular and molecular strategies allow the parasite to evade the human immune response for many cycles of parasite multiplication.
L H, Miller, M F, Good, G, Milon
openaire   +2 more sources

Anthrax Pathogenesis

Annual Review of Microbiology, 2015
Anthrax is caused by the spore-forming, gram-positive bacterium Bacillus anthracis. The bacterium's major virulence factors are (a) the anthrax toxins and (b) an antiphagocytic polyglutamic capsule. These are encoded by two large plasmids, the former by pXO1 and the latter by pXO2.
Mahtab, Moayeri   +4 more
openaire   +2 more sources

Rosacea Pathogenesis

Dermatologic Clinics, 2018
Rosacea is a chronic inflammatory skin disorder that is not fully understood but involves the complex interplay of genetic factors, immune dysregulation, neurovascular dysregulation, presence of microorganisms, and environmental factors. Increased activation of the immune system occurs through multiple stimuli, including increased levels of ...
Christine S, Ahn, William W, Huang
openaire   +2 more sources

Viroid Pathogenesis

2017
The small size and noncoding nature of viroid RNAs raises intriguing and specific questions about how they induce disease. The absence of viroid-encoded proteins, in sharp contrast to viruses, led originally to the assumption that viroid diseases were the result of direct interaction of the genomic viroid RNA (or its complement) with cellular ...
Flores R   +3 more
openaire   +3 more sources

Ulcerative Colitis: Pathogenesis

Current Drug Targets, 2011
The pathogenesis of ulcerative is still poorly understood. With the introduction of new culture-independent techniques the research on the intestinal microbiota has revealed an important reduction of Bacteroidetes and Firmicutes leading to a reduced biodiversity and dysbiosis in these patients.
FRIES, Walter, S. Comunale
openaire   +3 more sources

Scrapie pathogenesis

British Medical Bulletin, 1993
There is no specific marker for scrapie infectivity, and therefore no means other than prolonged bioassay for estimating levels of infection in tissues. Our knowledge of replication dynamics depends on precise rodent models which have enabled us to determine how the disease spreads and in which cells it replicates.
openaire   +2 more sources

Pathogenesis of Dermatophytosis

Mycopathologia, 2008
Despite the superficial localization of most dermatophytosis, host-fungus relationship in these infections is complex and still poorly elucidated. Though many efforts have been accomplished to characterize secreted dermatophytic proteases at the molecular level, only punctual insights have been afforded into other aspects of the pathogenesis of ...
Vermout, Sandy   +5 more
openaire   +3 more sources

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