Results 241 to 250 of about 1,694,622 (312)

Viral associations in multiple sclerosis: pathogenetic mechanisms and therapeutic implications. [PDF]

Virol J
Meshref M, Hussein AS, Allam SA, Moghib K, Younis H, Shalaby N.   +5 more
europepmc   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

The role of intestinal microbiota in the pathogenesis of childhood asthma. [PDF]

Front Immunol
Zhang L, Wu L, Shi C, Huang Q, Zhan L, Zeng Y, Deng Q.   +6 more
europepmc   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Correction: Primary Sjögren's syndrome-associated immune thrombocytopenia: from pathogenesis to treatment. [PDF]

Front Immunol
Zheng Z, He T, Zhang G, Fu G, Liu C.
europepmc   +1 more source

Astrocytic contributions to the pathogenesis of chronic traumatic encephalopathy: a scoping review. [PDF]

Chin Neurosurg J
Kubiak A, Hahn K, Powers N, Arroyo E, Vandello C, Martins J, He L.   +6 more
europepmc   +1 more source

Increased Levels of Serum Eosinophil-Derived Neurotoxin in Patients With Chronic Spontaneous Urticaria. [PDF]

Allergy Asthma Immunol Res
Yang EM, Kim HM, Seo J, Ye YM, Kim CK, Park HS.   +5 more
europepmc   +1 more source