Results 241 to 250 of about 460,180 (313)

Whole-Genome Sequencing of Pathogenic <i>Nigrospora musae</i> ST1 Causing Leaf Spot Disease in <i>Idesia polycarpa</i>. [PDF]

J Fungi (Basel)
Chen YZ, Chen Y, Yang J.
europepmc   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

SADS-CoV NS3 induces apoptosis by blocking the formation of Bcl-xL-BAK complex. [PDF]

J Virol
Mou C, Liu M, Xiang Y, Lin C, Zhang S, Shi K, Feng S, Ma J, Chen Z.   +8 more
europepmc   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Coinfection with infectious bronchitis virus exacerbates the pathogenicity of <i>Riemerella anatipestifer</i> in chickens. [PDF]

Front Vet Sci
Cong Y, Chen H, Gao Y, Ma X, Song X, Liu X, Li Y, Qin Z, Lv J.   +8 more
europepmc   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Identification and Management of a Novel Brown Spot Disease in Plums (<i>Prunus salicina</i> Lindl.). [PDF]

Plants (Basel)
Luo Y, Yang Y, Huang L, Liu C, Du X, Guo L, Ma H, Long M, Li S, Wang S, Sun X, Ma G.   +11 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Horizon: CNV interpretation through rapid automated ACMG-aligned pathogenicity analysis. [PDF]

Hum Genet
Eldesouky M, Shiyas S, Islam A, Hasan MN, Hossain MT, Akter H, Saiful M, Berdiev BK, Kuebler WM, Rahman P, Woodbury-Smith M, Hasan SM, Uddin M, Nassir N.   +13 more
europepmc   +1 more source