Results 71 to 80 of about 244,283 (268)

Lead exposure induces ferroptosis in ALS cell models by activating the MAPK/ERK signaling pathway

Ecotoxicology and Environmental Safety
Lead is a potent toxicant that exerts deleterious effects on multiple organ systems within the human body. Existing evidence suggests that lead exposure may contribute to the progression of amyotrophic lateral sclerosis (ALS).
Yi Gao, Bingxue Zheng, Xiaoxiao Peng, Nanxin Ma, Yan Qi, Xiaodie Lan, Ying Wang, Hongyan Zha, Chu Zhou, Fuying Liu, Qian Zhao, Hongyan Cao, Li Wang, Yulan Qiu, Jinping Zheng, Jian Guo   +15 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Estimating the causal effects of exposure mixtures: a generalized propensity score method

BMC Medical Research Methodology
Background In environmental epidemiology and many other fields, estimating the causal effects of multiple concurrent exposures holds great promise for driving public health interventions and policy changes. Given the predominant reliance on observational
Qian Gao, Ting Li, Guiming Zhu, Juping Wang, Kexin Qiu, Liangpo Liu, Xiujuan Yang, Tong Wang   +7 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Hourly ozone concentration estimation and its health impact study based on ensemble machine learning: A case study of Taiyuan City

环境与职业医学
BackgroundOzone (O3) is a major air pollutant. The existing monitoring system has uneven distribution of sites, insufficient coverage in underdeveloped areas, and low temporal resolution, making it difficult to obtain hourly data. This limits the dynamic
Rule DU, Xiaojuan YANG, Ruixia NIU, Yang XU, Guiming ZHU, Qian GAO, Tong WANG   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

“Should I stay or should I go”—a kinase delays escape of Candida glabrata from macrophages

mBio
Candida glabrata is an opportunistic fungal pathogen that causes both superficial and systemic infections in humans, accounting for 15%–25% of invasive candidiasis cases. Macrophages play a crucial role in antifungal immunity by internalizing C. glabrata;
Theresa Lange, Colin Clairet, Luisa Fischer, Raghav Vij, Johannes Sonnberger, Julia Mantke, Nadja Jablonowski, Eric Seemann, Britta Qualmann, Christophe d’Enfert, Lydia Kasper, Bernhard Hube, Sascha Brunke   +12 more
doaj   +1 more source

Rotavirus Pathogenicity

Virology, 1996
The pathogenicity of rotaviruses depends on multiple viral and host factors. In this review the evidence for the involvement of a number of viral genes in the ability to cause disease is presented. Different genes are of importance in different rotavirus-host systems: there is no single pathogenicity factor.
Burke, B, Desselberger, U
openaire   +3 more sources