Results 131 to 140 of about 1,804,540 (378)

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

PATHOLOGY [PDF]

open access: yesNeuro-Oncology, 1992
J.-i. Adachi   +199 more
openaire   +2 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

MYOCARDIODYSTROPHY IN CHILDREN FROM THE POINT OF VIEW OF PATHOANATOMIST

open access: yesВопросы современной педиатрии, 2011
The article discusses questions of etiology, pathogenesis and morphological signs of myocardiodystrophy in different periods of childhood. Functional disorders of cardiogenesis and hypoxic cardiopathy could be main causes of a disease.
B. I. Glukhovets
doaj   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Inflammatory Myofibroblastic Tumor of the Orbit: A Case Series and Literature Review

open access: yesJournal of Inflammation Research
Sitong Guo,1,2 Songze Wang,2,3 Chunli Chen,2 Xiaojin He,4 Bentao Yang,5 Zhiqin Huang,2 Jianmin Ma,2 Jitong Shi,2 Libin Jiang,2 Fred Kuanfu Chen6– 8 1Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050 ...
Guo S   +9 more
doaj  

Home - About - Disclaimer - Privacy