Results 141 to 150 of about 1,553,588 (294)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Clinical, pathological and molecular characteristics of patients with disease recurrence despite pathologic response to neoadjuvant ipilimumab plus nivolumab in stage III melanoma. [PDF]

Commun Med (Lond)
Versluis JM, Shehwana H, Elens R, Menzies AM, Reijers ILM, Dimitriadis P, Maher NG, van der Veldt AMM, Kapiteijn E, Broeks A, Scolyer RA, van de Wiel BA, van Akkooi ACJ, Schumacher TN, Long GV, Blank CU.   +15 more
europepmc   +1 more source

Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma

Nature Neuroscience, 2002
M. Gilbertson, M. Shenton, A. Ciszewski, K. Kasai, N. Lasko, S. Orr, R. Pitman   +6 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Development and Validation of a Diagnostic Nomogram for Pathologic Myopia in Patients with High Myopia and Tessellated Fundus: A Cross-Sectional Study. [PDF]

Risk Manag Healthc Policy
Zuo H, Huang H, Huang B, He J, Liu X, Zhou H, Huang L, Bi F, Huang M.   +8 more
europepmc   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Use of the IlluminOss Implant for Treating a Pathologic Humeral Fracture in a Patient with Renal Cell Carcinoma Metastasis: A Case Report. [PDF]

J Orthop Case Rep
Drees SM, Nair A, Swigart P, Unver L, Yatsonsky D, Andrews KA.   +5 more
europepmc   +1 more source

Stage IIIA pathologic N2 non-small cell lung cancer patients may maximize benefit from preoperative radiotherapy: a population-based study

, 2020
Hongxia Duan, Long Liang, Shuanshuan Xie, Changhui Wang   +3 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Intersection of Black race and carbohydrate antigen 19-9 nonproduction underpins worse pathologic response to neoadjuvant therapy in pancreatic cancer. [PDF]

Cancer
Martos MP, Dickey EM, Abdilleh K, Ahmad SA, Maithel SK, Leigh-Matijakovich N, Kim HJ, Abbott DE, Zafar SN, Kooby DA, Parikh AA, Hosein PJ, Merchant NB, Datta J, Hester CA.   +14 more
europepmc   +1 more source