Results 1 to 10 of about 1,071,956 (242)

OBSERVATIONS ON THE PATHOLOGICAL CHANGES FOLLOWING EXPERIMENTAL HYPERTENSION PRODUCED BY CONSTRICTION OF THE RENAL ARTERY [PDF]

Journal of Experimental Medicine, 1938
The clinical histories and pathological findings of six animals dying within a few days following bilateral constriction of the renal arteries have been presented. No explanation for the rise in blood pressure was found. The clinical histories and pathological findings of twelve animals with a sustained hypertension have been considered ...
Charles G. Child
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An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. [PDF]

Nature Communications, 2016
Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma.
Abagyan, Ruben, Acharya, Chayan, Baker, Kent A, Bennett, Brad C, Harris, Andrew L, McIntire, William E, Purdy, Michael D, Stevens, Raymond C, Yeager, Mark, Zhang, Qinghai   +9 more
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The effects of curvature and constriction on airflow and energy loss in pathological tracheas

Respiratory Physiology & Neurobiology, 2016
This paper considers factors that play a significant role in determining inspiratory pressure and energy losses in the human trachea. Previous characterisations of pathological geometry changes have focussed on relating airway constriction and subsequent pressure loss, however many pathologies that affect the trachea cause deviation, increased ...
Alister J. Bates, R. Cetto, Denis Doorly, R. C. Schroter, Neil Tolley, Andrew Comerford   +5 more
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Identification of differentially expressed genes and preliminary validations in cardiac pathological remodeling induced by transverse aortic constriction

International Journal of Molecular Medicine, 2019
Cardiac remodeling predisposes to heart failure if the burden is unresolved, and heart failure is an important cause of mortality in humans. The aim of the present study was to identify the key genes involved in cardiac pathological remodeling induced by pressure overload.
Hui‐Bo Wang, R. Stephanie Huang, Kang Yang, Man Xu, Di Fan, Ming‐Xin Liu, Sihui Huang, Libo Liu, Hai‐Ming Wu, Qi‐Zhu Tang   +9 more
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PATHOLOGICAL EVALUATION OF DORSAL ROOT GANGLIA AND SPINAL CORD AND SCIATIC NERVE FOLLOWING A CHRONIC CONSTRICTION INJURY OF THE SCIATIC NERVE IN RATS [PDF]

Kafrelsheikh Veterinary Medical Journal, 2019
Objective: To study pathological changes on spinal cord and dorsal root ganglia (DRG) and sciatic nerve itself after sciatic nerve injury in rats Design: Randomized experimental study Procedure:  Rats were randomly divided into two main groups. Control group (25 rats) without any treatment and treated group (n=50) with induced chronic constriction ...
Al-Shimaa E Elsayed, Walaa Awadin, Marwa Abass, Mohamed F. Hamed   +3 more
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Use of Constrained Nonlinear Kalman Filtering to Detect Pathological Constriction of Cerebral Arterial Blood Vessels

, 2009
Estimation of lumped cerebral arterial radius is important for healthcare monitoring in ICU patients, specially for detecting the presence of vasospasm following Subarachnoid Hemorrhage. A technique for continuous monitoring based on available measurements without introducing any additional invasive technique is very attractive, and would allow ...
Sara M. Federico, Shadnaz Asgari, Paul Vespa, Ali H., Marvin Bergsneider, Xiao Hu   +5 more
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MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts. [PDF]

PLoS ONE, 2013
Downregulation of the muscle-specific microRNA-1 (miR-1) mediates the induction of pathologic cardiac hypertrophy. Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular ...
Antonio Curcio, Daniele Torella, Claudio Iaconetti, Eugenia Pasceri, Jolanda Sabatino, Sabato Sorrentino, Salvatore Giampà, Mariella Micieli, Alberto Polimeni, Beverley J Henning, Angelo Leone, Daniele Catalucci, Georgina M Ellison, Gianluigi Condorelli, Ciro Indolfi   +14 more
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Inhibiting Receptor of Advanced Glycation End Products Attenuates Pressure Overload-Induced Cardiac Dysfunction by Preventing Excessive Autophagy

Frontiers in Physiology, 2018
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy.
Wenbin Gao, Wenbin Gao, Wenbin Gao, Zheng Zhou, Zheng Zhou, Zheng Zhou, Birong Liang, Birong Liang, Birong Liang, Yusheng Huang, Yusheng Huang, Yusheng Huang, Zhongqi Yang, Zhongqi Yang, Zhongqi Yang, Yang Chen, Yang Chen, Lu Zhang, Lu Zhang, Lu Zhang, Cui Yan, Cui Yan, Cui Yan, Jiajia Wang, Jiajia Wang, Jiajia Wang, Lu Lu, Lu Lu, Lu Lu, Zhaorui Wen, Zhaorui Wen, Shaoxiang Xian, Shaoxiang Xian, Shaoxiang Xian, Lingjun Wang, Lingjun Wang, Lingjun Wang   +36 more
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Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway.

PLoS ONE, 2016
AimsAlthough extracellular-regulated kinases (ERK) are a well-known central mediator in cardiac hypertrophy, no clinically available ERK antagonist has been tested for preventing cardiac hypertrophy.
Chen Li, Zhongxiu Chen, Hao Yang, Fangbo Luo, Lihong Chen, Huawei Cai, Yajiao Li, Guiying You, Dan Long, Shengfu Li, Qiuping Zhang, Li Rao   +11 more
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CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis [PDF]

Cell Death Discovery
Pathological cardiac hypertrophy is an independent risk factor for heart failure. Disruption of mitochondrial protein homeostasis plays a key role in pathological cardiac hypertrophy; however, the mechanism of maintaining mitochondrial homeostasis in ...
Lei Shi, Yanzhen Tan, Wenying Zheng, Guojie Cao, Haitao Zhou, Panpan Li, Jun Cui, Yujie Song, Lele Feng, Hong Li, Wenju Shan, Bing Zhang, Wei Yi   +12 more
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