Results 1 to 10 of about 1,422,521 (300)

Inhibiting Receptor of Advanced Glycation End Products Attenuates Pressure Overload-Induced Cardiac Dysfunction by Preventing Excessive Autophagy

Frontiers in Physiology, 2018
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy.
Wenbin Gao, Wenbin Gao, Wenbin Gao, Zheng Zhou, Zheng Zhou, Zheng Zhou, Birong Liang, Birong Liang, Birong Liang, Yusheng Huang, Yusheng Huang, Yusheng Huang, Zhongqi Yang, Zhongqi Yang, Zhongqi Yang, Yang Chen, Yang Chen, Lu Zhang, Lu Zhang, Lu Zhang, Cui Yan, Cui Yan, Cui Yan, Jiajia Wang, Jiajia Wang, Jiajia Wang, Lu Lu, Lu Lu, Lu Lu, Zhaorui Wen, Zhaorui Wen, Shaoxiang Xian, Shaoxiang Xian, Shaoxiang Xian, Lingjun Wang, Lingjun Wang, Lingjun Wang   +36 more
doaj   +2 more sources

MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts. [PDF]

PLoS ONE, 2013
Downregulation of the muscle-specific microRNA-1 (miR-1) mediates the induction of pathologic cardiac hypertrophy. Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular ...
Antonio Curcio, Daniele Torella, Claudio Iaconetti, Eugenia Pasceri, Jolanda Sabatino, Sabato Sorrentino, Salvatore Giampà, Mariella Micieli, Alberto Polimeni, Beverley J Henning, Angelo Leone, Daniele Catalucci, Georgina M Ellison, Gianluigi Condorelli, Ciro Indolfi   +14 more
doaj   +2 more sources

The analysis of a sudden death caused by the unusual shape of the foramen magnum stenosis [PDF]

Vojnosanitetski Pregled, 2021
Introduction. The anomalies of the size and shape of the foramen magnum (FM), followed by its stenosis, take a special place in clinical and forensic practice.
Vuković Miloš, Vuković Jelena, Maletin Miloš, Vuković Radenko   +3 more
doaj   +1 more source

Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart

Journal of Molecular and Cellular Cardiology, 2021
The temporal nature of chromatin structural changes underpinning pathologic transcription are poorly understood. We measured chromatin accessibility and DNA methylation to study the contribution of chromatin remodeling at different stages of cardiac ...
Douglas J. Chapski, M. Cabaj, Marco Morselli, Rosibel J Mason, Elizabeth Soehalim, Shu-Xun Ren, M. Pellegrini, Yi-Bin Wang, T. Vondriska, M. Rosa-Garrido   +9 more
semanticscholar   +1 more source

An infrequent cause of neonatal upper airway obstruction: Congenital nasal pyriform aperture stenosis presenting to a remote facility

Pediatric Investigation, 2021
Introduction Congenital nasal pyriform aperture stenosis (CNPAS) is a rare congenital condition of structural nasal obstruction. Respiratory distress, stertor, and poor feeding are often presenting features.
Tahne Joseph Lahiff, Viliame Sotutu, Smrdhi Sarachandran, Lucas Speed, Vishal Saddi   +4 more
doaj   +1 more source

Liver Graft Failure after Plastic Stent Removal of an Anastomotic Biliary Stricture

The Korean Journal of Gastroenterology, 2022
A biliary anastomotic stricture developed 13 months after living donor liver transplantation in a 19-year-old male with congenital hepatic fibrosis. Endoscopic management with balloon dilation followed by the placement of a 7F plastic stent was performed
Jung Won Chun, Nam-Joon Yi, Haeryoung Kim, Woo Hyun Paik   +3 more
doaj   +1 more source

Constrictive pericarditis: a known pathology with a new aetiology [PDF]

Journal of Cardiothoracic Surgery, 2015
Pericardectomy remains the only available treatment for constrictive pericarditis. Historically idiopathic was the main aetiology for CP followed by TB. In recent years we have seen a change in the aetiology of CP with increasing PCI and surgical interventions.
Ahmed, Suhaib, ElBasheir, H, Nzewi, OC
openaire   +1 more source

Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease [PDF]

International Journal of Molecular Sciences, 2021
Activation of the Ca2+ activated Cl− channel TMEM16A is proposed as a treatment in inflammatory airway disease. It is assumed that activation of TMEM16A will induce electrolyte secretion, and thus reduce airway mucus plugging and improve mucociliary clearance.
Kunzelmann, Karl, Centeio, Raquel, Ousingsawat, Jiraporn, Cabrita, Inês, Schreiber, Rainer, Talbi, Khaoula, Benedetto, Roberta, Doušová, Tereza, Verbeken, Eric K., De Boeck, Kris, Cohen, Isaac   +10 more
openaire   +2 more sources

Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure

Circulation: Heart Failure, 2020
Supplemental Digital Content is available in the text. Background: Accumulating evidence suggests that the failing heart reprograms fuel metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone delivery ameliorates ...
Salva R. Yurista, T. Matsuura, H. Silljé, K. Nijholt, K. McDaid, Swapnil V. Shewale, T. Leone, J. Newman, E. Verdin, D. van Veldhuisen, R. D. de Boer, D. Kelly, B. Westenbrink   +12 more
semanticscholar   +1 more source

Intestinal Stricture in Crohn's Disease [PDF]

Intestinal Research, 2015
Crohn's disease (CD) is a disease with chronic inflammation of unknown etiology involving any part of the gastrointestinal tract. The incidence and prevalence of CD are increasing recently in Asia.
Chen-Wang Chang, Jau-Min Wong, Chien-Chih Tung, I-Lun Shih, Horng-Yuan Wang, Shu-Chen Wei   +5 more
doaj   +1 more source