Results 121 to 130 of about 25,821 (323)

Tratamento da estenose umbilical em paciente com dermolipectomia vertical Treatment of the umbilical stenosis in a vertical dermolipectomy patient

Revista Brasileira de Cirurgia Plástica, 2011
INTRODUÇÃO: As alterações inestéticas da cicatriz umbilical em abdominoplastias verticais são frequentes fatores de insatisfação com os resultados. RELATO DE CASO: Apresentamos neste artigo um caso de estenose umbilical em paciente com dermolipectomia ...
André Luis Rosenhaim Monte
doaj   +1 more source

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]

, 2017
Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz, Harada, Eri, Ishikawa, Tatsuya, Kitajima, Naoyuki, Kumagai, Yoshito, Nishida, Motohiro, Nishimura, Akiyuki, Numaga Tomita, Takuro, Oda, Sayaka, Shimauchi, Tsukasa, Tomizaki, Takashi   +10 more
core   +1 more source

Affinity‐Based Isolation and One‐Pot Analysis of Extracellular Vesicles from Biofluids Using Phase Separated Zwitterionic Coacervates

Advanced Science, EarlyView.
This study presents a novel method for affinity‐based isolation and analysis of extracellular vesicles from biofluids using phase‐separated zwitterionic coacervates functionalized with a membrane‐sensing peptide. This technology minimizes nonspecific binding, enabling high‐yield isolation and direct one‐pot biomarker profiling.
Francesca Torrini, Roberto Frigerio, Jonathan Garlipp, Philippe Lenzen, Karl Normak, Carolina Paganini, Marina Cretich, Alessandro Gori, Paolo Arosio   +8 more
wiley   +1 more source

Could a phase model help to improve translational animal research?

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 550-556, December 2022., 2022
Transferability of findings from animal research to the human organism is controversially discussed. We propose a phase model which refers to the well‐known process of clinical research in order to improve decision‐making regarding the evidence which is gained in translational animal research.
Benjamin Mayer, Jan Tuckermann, Rainer Muche   +2 more
wiley   +1 more source

Noscapine AntagonizesVasoconstrictor Action of Bradykinin in Isolated Human Umbilical Artery

Medical Journal of The Islamic Republic of Iran, 2011
Background: It has been demonstrated that noscapine, an antitussive opioid alkaloid, could antagonize bradykinin- induced responses such as bradykinin effects in guinea-pig ileum, cough induced by radykinin receptor agonist and angiotensin converting ...
Massoumeh Shafiei, Massoud Mahmoudian, Nahid Aboutaleb, Farahnaz Beiranvand, Ashraf-Alsadat Moazzam   +4 more
doaj  

Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal [PDF]

, 2011
Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis.
Akin C, Akin C, Akin C, Alberto Orfao, Alvarez-Twose I, Arock M, Arredondo AR, Austen KF, Awad JA, Bodemer C, Boguslaw Nedoszytko, Bonadonna P, Butterfield JH, Castells MC, Cem Akin, Chin KW, Costa JJ, Daley T, Dean D. Metcalfe, Di Lorenzo G, Donker ML, Finkelman FD, Galli SJ, Garcia-Montero AC, Golden DB, González de Olano D, Hans-Peter Horny, Hogan AD, Horny HP, Johansson SG, Jordan JH, Joseph H. Butterfield, Karin Hartmann, Karl Sotlar, Knut Brockow, Lawrence B. Schwartz, Lieberman P, Luis Escribano, Maintz L, Mariana Castells, Massimo Triggiani, Melody C. Carter, Metcalfe DD, Metcalfe DD, Metcalfe DD, Michel Arock, Morel AM, Murphy S, Nedoszytko B, Peavy RD, Peter Valent, Philip Lieberman, Rivera J, Rudolf Valenta, Ruëff F, Samorapoompichit P, Sampson HA, Schwartz LB, Schwartz LB, Schwartz LB, Schwelberger HG, Serafin WE, Sonneck K, Sperr WR, Vadas P, Valent P, Valent P, Valent P, Valent P, Valent P, van der Donk EM, van Toorenenbergen AW, Webb LM, Wolfgang R. Sperr   +73 more
core   +1 more source

A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis

Advanced Science, EarlyView.
The circRNA circNAB1 is downregulated in AF patient. Silencing circNAB1 promotes collagen deposition and inflammation, whereas overexpression reduces AF susceptibility. circNAB1 encodes the protein NAB1 356 that interacts with EGR1 to mitigate fibrosis and inflammation.
William W Du, Muhammad Rafiq, Hui Yuan, Xiangmin Li, Sheng Wang, Jun Wu, Jinfeng Wei, Ren‐Ke Li, Huiming Guo, Burton B Yang   +9 more
wiley   +1 more source

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

Advanced Science, EarlyView.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li, Ting Liu, Yan Wang, Yangpeng Li, Leiying Liu, James Bae, Yu He, Xian Luo, Zhu Liu, Tangting Chen, Xianhong Ou, Dan Zhang, Huan Lan, Juyi Wan, Yan Wei, Fang Zhao, Xin Wang, Tao Li, Christopher L.‐H. Huang, Chunxiang Zhang, Ming Lei, Xiaoqiu Tan   +21 more
wiley   +1 more source

Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy [PDF]

, 2014
Exome sequencing revealed a homozygous missense mutation (c.317C>G [p.Arg106Pro]) in POC1B, encoding POC1 centriolar protein B, in three siblings with autosomal-recessive cone dystrophy or cone-rod dystrophy and compound-heterozygous POC1B mutations (c ...
Arts, Heleen H, Coppieters, Frauke, Cremers, Frans PM, De Baere, Elfride, de Vrieze, Erik, den Hollander, Anneke I, Hetterschijt, Lisette, Hoyng, Carel B, Kremer, Hannie, Lambertus, Stanley, Lamers, Ideke JC, Letteboer, Stef JF, Peters, Theo A, POC1B Study Group, the, Roepman, Ronald, Roosing, Susanne, van den Born, L Ingeborgh, van Wijk, Erwin   +17 more
core   +2 more sources

A Knowledge‐Guided Graph Learning Approach Bridging Phenotype‐ and Target‐Based Drug Discovery

Advanced Science, EarlyView.
Knowledge‐Guided Drug Relational Predictor (KGDRP), a graph representation learning approach, effectively integrates multiple omics data, including biological network data, gene expression data, and sequence data that incorporates chemical molecular structures.
Qing Ye, Yundian Zeng, Linlong Jiang, Yu Kang, Peichen Pan, Jiming Chen, Yafeng Deng, Haitao Zhao, Shibo He, Tingjun Hou, Chang‐Yu Hsieh   +10 more
wiley   +1 more source