Results 181 to 190 of about 1,072,961 (339)

Mineralocorticoid Receptor Deficiency in T Cells Attenuates Pressure Overload–Induced Cardiac Hypertrophy and Dysfunction Through Modulating T-Cell Activation

open access: yesHYPERTENSION, 2017
Chao Li   +15 more
semanticscholar   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

open access: yesAdvanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei   +10 more
wiley   +1 more source

Reoperative pouch surgery for suspected Crohn's‐related complications aided by biologic coverage: Early experience from an inflammatory bowel disease center

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This paper demonstrates that revisional/redo ileal pouch anal anastomosis (IPAA) surgery with concurrent biologic therapy provides a viable, stoma‐free alternative for patients with Crohn's disease‐like complications, showing a high functioning pouch rate and expanding options for managing pouch failure.
Mehmet Gulmez   +8 more
wiley   +1 more source

Immunostimulatory DNA Tetrahedron‐Based Nanovaccine Combined With Immune Checkpoint PD‐1 Blockade for Boosting Systemic Immune Responses Against Oral Squamous Cell Carcinoma

open access: yesAggregate, EarlyView.
This study introduces an immunomodulatory DNA tetrahedral framework nucleic acid‐based nanovaccine tFNA‐CpG. The functionalized nanovaccine shows stable and well‐defined morphological characteristics and can be efficiently taken up by APCs. When combined with the immune checkpoint inhibitor anti‐PD‐1, it notably ameliorated the immunosuppressive ...
Xueting Yang   +12 more
wiley   +1 more source

Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

open access: yesAggregate, EarlyView.
Triterpenoids serve as both exceptional molecular motifs for supramolecular assembly and versatile therapeutic agents, offering broad biological functions to improve health outcomes and enhance treatment efficacy. This review comprehensively summarizes recent advances in triterpenoid‐based supramolecular systems, including their roles as functional ...
Jie Zhong   +3 more
wiley   +1 more source

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