Results 231 to 240 of about 1,072,961 (339)

Refractory Benign Duodenal Stenosis Successfully Treated With Endoscopic Spray Cryotherapy. [PDF]

ACG Case Rep J
Khan NI, Chandan S, Abbasi A, Pathak S, Kadkhodayan KS.   +4 more
europepmc   +1 more source

Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges

Animal Models and Experimental Medicine, EarlyView.
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley   +1 more source

The Use of Corticosteroids in Patients With Pleural and Pericardial Tuberculosis. [PDF]

J Community Hosp Intern Med Perspect
Sang J, Motes A, Nugent K.
europepmc   +1 more source

Influence of the arterial elastic component on the response to balloon angioplasty in femoral arteries of a healthy porcine model

Animal Models and Experimental Medicine, EarlyView.
This study evaluates the role of elastin in vascular response 28 days after balloon angioplasty using uncoated and paclitaxel‐coated balloons in a healthy porcine model. The results show higher elastin content in external femoral arteries, which is inversely correlated with vascular injury, inflammation, smooth muscle cell loss, proteoglycan and fibrin
María Gracia de Garnica García, Marina Gil Bernabé, Claudia Pérez‐Martínez, Laura Mola Solà, Luis Duocastella Codina, María Molina Crisol, Alex Gómez Castel, Armando Pérez de Prado   +7 more
wiley   +1 more source

Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery. [PDF]

Respir Res
Koziol-White C, Gebski E, Cao G, Panettieri RA.   +3 more
europepmc   +1 more source

Rapid severe hypertension and organ damage in two‐kidney two‐clip rats produced by different sizes of clips

Animal Models and Experimental Medicine, EarlyView.
Blood pressure increases immediately when the 2K2C rats (made with 0.3, 0.25, and 0.2 mm U‐shaped clips) regain consciousness from anesthesia. 100% of the rats develop hypertension on the day of 2K2C surgery. Blood pressure continues to rise, resulting in severe hypertension and organ damage to the brain, heart, aorta, and kidneys at 1, 2, 4, and 6 ...
Jia‐Sheng Tian, Qi‐Sheng Ling, Yu‐Chen Wei, Dao‐Xin Wang, Chao‐Yu Miao   +4 more
wiley   +1 more source

Machine Learning‐Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands

Angewandte Chemie, EarlyView.
This study combines computational and experimental approaches to study how natural and synthetic small molecules interact with the ZTP riboswitch, a bacterial RNA element that regulates gene expression. Using chemical synthesis, biochemical approaches, and artificial intelligence augmented MD simulations, we analyze both ligand binding and riboswitch ...
Christopher R. Fullenkamp, Shams Mehdi, Christopher P. Jones, Logan Tenney, Patricio Pichling, Peri R. Prestwood, Adrian R. Ferré‐D'Amaré, Pratyush Tiwary, John S. Schneekloth   +8 more
wiley   +2 more sources

Application of fibrobronchoscopy-guided aortic suspension in pediatric patients with bronchial compression resulting from repair of coarctation of the aorta: a case report. [PDF]

BMC Pediatr
Tan H, Zou X, Gong K, Yang Y, Wu Z, Liu J, Wu S.   +6 more
europepmc   +1 more source

SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy

Animal Models and Experimental Medicine, EarlyView.
Sox6 expression is elevated in hypertensive conditions and promotes vascular smooth muscle cell phenotypic switching through autophagy activation. Using gain‐ and loss‐of‐function approaches both in vitro and in vivo, we demonstrate that Sox6 regulates blood pressure and vascular remodeling, highlighting its potential as a novel therapeutic target for ...
Qianhui Ling, Xilan Dong, Liyan Mao, Chengjun Huang, Linjing Cong, Haizeng Zhang, Jun Cai, Zhenzhen Chen   +7 more
wiley   +1 more source

Enhancing Clinical Detection Accuracy of Large Structured Viral RNA via DNAzyme Cleavage and Antisense‐Assisted Rolling Circle Amplification

Angewandte Chemie, EarlyView.
We show that antisense oligonucleotides can be used to restructure secondary structural elements around the circular DNA template binding sites of the genomic RNA for subsequent rolling circle amplification. This strategy was employed to identify otherwise COVID “false negative” saliva samples by accurately detecting the presence of SARS‐CoV‐2 genomic ...
Amal Mathai, Jimmy Gu, Connor Nurmi, John D. Brennan, Yingfu Li   +4 more
wiley   +2 more sources