Results 111 to 120 of about 2,638,293 (327)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Porto-Sinusoidal Vascular Disease: A New Nomenclature Different from Idiopathic Non-Cirrhotic Portal Hypertension

Diagnostics
Background and Aims: Porto-sinusoidal vascular disease (PSVD) as a novel clinical conception was modified on the basis of idiopathic non-cirrhotic portal hypertension (INCPH).
Jie Liu, Qian Zhang, Yao Liu, Hai-Xia Ma, Xu Han, Ying Ma, Li-Li Zhao, Jia Li   +7 more
doaj   +1 more source

Note on pathological changes found in the embryo pig and its membranes [PDF]

, 1908
Henry S. Denison
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Analysis of mortality in François’ langurs (Trachypithecus francoisi) managed care in Trachypithecus francoisi rare animal breeding Center in Wuzhou, Guangxi, China: a 16-year review

Frontiers in Veterinary Science
In managed care settings, primates are susceptible to a variety of health complications. A comprehensive understanding of the causes of mortality and their association with management practices is essential for enhancing the welfare of managed care ...
Yi Xiong, Yi Xiong, Guanping Xie, Guanping Xie, Yifeng Li, Yasheng Mo, Zhengjun Wu, Zhengjun Wu, Youbang Li, Youbang Li   +9 more
doaj   +1 more source

Azaserine: Pathological and pharmacological studies [PDF]

, 1957
Stephen S. Sternberg, Frederick S. Philips, Barbara B. Adams, Beatrice N. Greene, Barbara Wheelock   +4 more
openalex   +1 more source

Therapeutic target discovery using Boolean network attractors: improvements of kali

, 2018
In a previous article, an algorithm for identifying therapeutic targets in Boolean networks modeling pathological mechanisms was introduced. In the present article, the improvements made on this algorithm, named kali, are described.
Guziolowski, Carito, Poret, Arnaud
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Ecotopic infection of cattle with Fasciola gigantica: parasitological and pathological studies

The Iraqi Journal of Veterinary Medicine, 1999
Out of 1250 bovine fasciolliasis. 10 cattle were found to have lung fascioliasis, one cow had abomasal fascioliasis and another one wih renal fascioliasis.
R. Y. AL-Kubaisee, M. J. Alwan, B. AL- Kaisee   +2 more
doaj   +1 more source

Clinical and Pathological Report of the Rotunda Hospital, Dublin, for the Year 1904–5.* [PDF]

, 1906
E. Hastings Tweedy, Arthur N. Holmes, Robert J. Rowlette   +2 more
openalex   +1 more source