Results 71 to 80 of about 2,815,174 (287)

Therapeutic target discovery using Boolean network attractors: avoiding pathological phenotypes [PDF]

, 2014
Target identification, one of the steps of drug discovery, aims at identifying biomolecules whose function should be therapeutically altered in order to cure the considered pathology.
Boissel, Jean-Pierre, Poret, Arnaud
core   +4 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Genome sequence of Enterococcus mundtii EM01, isolated from Bombyx mori midgut and responsible for flacherie disease in silkworms reared on an artificial diet [PDF]

, 2018
The whole genome sequence of Enterococcus mundtii strain EM01 is reported here. The isolate proved to be the cause of flacherie in Bombyx mori. To date, the genomes of 11 other E. mundtii strains have been sequenced.
Campanaro, Stefano, Cappellozza, Silvia, de Diego-Diaz, Beatriz, Duarte, Vinicius da Silva, Saviane, Alessio, Squartini, Andrea, Treu, Laura   +6 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Sporadic Creutzfeldt–Jakob disease is associated with reorganization of metabolic connectivity in a pathological brain network [PDF]

, 2022
Tomaž Rus, Jernej Mlakar, Luka Ležaić, An Vo, Nha Nguyen, Chris C. Tang, Michele Fiorini, Elena Prieto, Gloria Martí‐Andrés, Javier Arbizu, David Eidelberg, Maja Trošt   +11 more
openalex   +1 more source

LU factorization with panel rank revealing pivoting and its communication avoiding version [PDF]

, 2012
We present the LU decomposition with panel rank revealing pivoting (LU_PRRP), an LU factorization algorithm based on strong rank revealing QR panel factorization. LU_PRRP is more stable than Gaussian elimination with partial pivoting (GEPP).
Demmel, James W., Grigori, Laura, Gu, Ming, Khabou, Amal   +3 more
core   +8 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Topical Application to Mixture of Honey with Cod Liver Oil as a Novel Therapy to Treat Contaminated Skin Wounds in Rabbits Model

Kufa Journal for Veterinary Medical Sciences, 2017
Contaminated wounds are common in all animals and human being; their treatments may complicated and need for prolong duration, therefore the current study aimed to investigate an alternative way to treat the contaminated wounds by using natural compounds
Jihad Abdulameer Ahmed, Jinan A. Bannai, Rana K. Abdulsamad   +2 more
doaj   +1 more source

Impaired decisional impulsivity in pathological videogamers [PDF]

, 2013
Background Pathological gaming is an emerging and poorly understood problem. Impulsivity is commonly impaired in disorders of behavioural and substance addiction, hence we sought to systematically investigate the different subtypes of decisional and ...
A Johansson, AD Castel, AJ Lawrence, AR Aron, AT Beck, CH Ko, CJ Ferguson, CS Green, D Belin, D Gentile, DA Gentile, DD Li, DH Han, DH Han, DL King, DR Topor, DV Sheehan, Edward T. Bullmore, G Porter, GD Logan, H Choo, HS Park, JL Perry, JP Charlton, JS Lemmens, JS Lemmens, KD Ersche, KN Kirby, KN Kirby, KW Beard, L Clark, L Diergaarde, Leonardo Fontenelle, M Littel, MD Griffiths, Michael A. Irvine, MJ Koepp, Neil A. Harrison, NM Petry, RA Tejeiro Salguero, RAT Salguero, RC Lorenz, RJ Li, RJ van Holst, S Kuhn, S Pallanti, Sorcha Bolton, SP Whiteside, TW Robbins, Valerie Voon, WK Goodman, Yulia Worbe   +51 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source