Results 51 to 60 of about 7,983,647 (299)

Clinico-pathological predictors of clinical complete response in rectal cancer

Cancer Treatment and Research Communications, 2022
Prediction of clinical complete response in rectal cancer before neoadjuvant chemo-radiotherapy treatment enables treatment selection. Patients predicted to have complete response could have chemo-radiotherapy, and others could have additional doublet chemotherapy at this stage of their treatment to improve their overall outcome. This work investigates
P. Mbanu, E. Vasquez Osorio, H. Mistry, L. Malcomson, S. Yousif, M. Aznar, R. Kochhar, M. Van Herk, A.G. Renehan, M.P. Saunders   +9 more
openaire   +3 more sources

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

The Role of Magnetic Resonance Imaging in Predicting Pathological Complete Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy [PDF]

Objective: Neoadjuvant chemotherapy (NACT) has been used more frequently in the treatment of non-metastatic breast cancer. Achieving a pathological complete response (pCR) after NACT provides us with information about the prognosis of the disease.
Emre Özge, Rıza Umar Gürsu, İlkay Gültürk, Çiğdem Usul, Emine Sevcan Ata, Melis Baykara Ulusan, Bünyamin Güney, Özgür Han   +7 more
core   +1 more source

An additional peril of pathologic complete response

Radiotherapy and Oncology
Pathological complete response (pCR) has been shown to predict long-term outcomes in breast cancer patients undergoing primary systemic therapy in aggressive early breast cancer. Herein we discuss the caveats of determining pCR, and data needed to tailor breast cancer radiation after pCR.
Orit Kaidar-Person, Philip Poortmans, Icro Meattini, Trine Tramm   +3 more
openaire   +5 more sources

Preoperative chemoradiation in carcinoma esophagus: Experience from a tertiary cancer center in India

Indian Journal of Medical and Paediatric Oncology, 2018
Background: Esophageal cancer is the fourth most common cause of cancer-related deaths in India. In 2012, the CROSS trial evaluated the benefit of induction therapy using weekly carboplatin-paclitaxel with 41.4 Gy radiation versus surgery alone ...
Harjot Kaur Bajwa, Rohith Singareddy, Mahendra M Reddy, Krishnam A Raju, Subramanyeshwar T Rao, Senthil J Rajappa   +5 more
doaj   +1 more source

The implications of a pathological complete response of the primary tumour after neoadjuvant chemotherapy for breast cancer on axillary surgery

Journal of the Egyptian National Cancer Institute, 2021
Background Management of the node-positive axilla after neoadjuvant chemotherapy is controversial. The aim of this study is to predict the group of patients who may require a less invasive approach for axillary management. One possible group are patients
Mina M. G. Youssef, Ahmed A. Metwally, Tamer M. Manie   +2 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Lymph node ratio is a prognostic indicator for locally advanced gastric cancer after neoadjuvant immunochemotherapy

BMC Gastroenterology
Objective The efficacy of lymph node ratio (LNR) as a prognostic indicator in locally advanced gastric cancer (LAGC) patients underwent radical resection after neoadjuvant immunochemotherapy (NICT) remains to be demonstrated. The objective of the current
Pei Zhou, Xiong Sun, Liwu Zeng, Xinyu Zeng, Gengchen Xie, Xinghua Liu, Kaixiong Tao, Peng Zhang   +7 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Pathological complete response in advanced gastric stromal tumor after imatinib mesylate therapy: a case report [PDF]

, 2011
Introduction Gastrointestinal stromal tumors are a rare neoplasm exhibiting, in most cases, mutations of c-kit. Imatinib mesylate is the standard treatment for patients who have advanced gastrointestinal stromal tumors.
Ossaden Abdelmalek, Kaoutar Znati, El Mrabet Fatima, Amarti Affaf, Yousra Akasbi, Brahmi Sami, Abdelmalek Ossaden, Ibrahimi Adil, Khalid Maazaz, Khalid Ait Taleb, Taleb Khalid, Sami Aziz Brahmi, Affaf Amarti, Touyar Anas, Akasbi Yousra, Znati Kaoutar, El Mesbahi Omar, Siham Tizniti, Omar El Mesbahi, Anas Touyar, Adil Ibrahimi, Maazaz Khalid, Tizniti Siham, Fatima Zahra El Mrabet   +23 more
core   +2 more sources