Results 61 to 70 of about 7,983,647 (299)

A Predictive Model to Evaluate Pathologic Complete Response in Rectal Adenocarcinoma

Technology in Cancer Research & Treatment, 2023
Introduction: Neoadjuvant chemo-radiotherapy (nCRT) before surgery was a standard treatment strategy for locally advanced rectal cancer (LARC). The aim of this study was to assess the relationship between the predictive factors and pathological complete response (pCR) in rectal cancer patients, especially in ultra-low ones.
Shuiwang Qing, Lei Gu, Tingting Du, Xiaolan Yin, Ke-jia Zhang, Huo-jun Zhang   +5 more
openaire   +3 more sources

The prognostic power of major pathological response in esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multi-center cohort study

Frontiers in Immunology
BackgroundFor esophageal squamous cell carcinoma(ESCC), neoadjuvant chemoimmunotherapy (nICT) constitutes an innovative therapeutic strategy. However, The relationship between its short-term efficacy and long-term prognosis requires further clarification.
Shuhan Xie, Shuhan Xie, Shuhan Xie, Shuhan Xie, Shijie Huang, Zilu Tang, Hai Zhang, Jinxin Xu, Sunkui Ke, Jinbiao Xie, Rongyu Xu, Ying Chen, Zhinuan Hong, Zhinuan Hong, Zhinuan Hong, Zhinuan Hong, Mingqiang Kang, Mingqiang Kang, Mingqiang Kang, Mingqiang Kang   +19 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Summary of pathological complete response rates in different subsets.

, 2019
Summary of pathological complete response rates in different subsets.
Sujata Patil (674937), Geoffrey Lindeman (62068), Mustafa Khasraw (6335354), Andrea Muscat (267150), Ian Collins (421015), David Ashley (143624), Violet Mukaro (6335342), Linda West (6335345), Wei Shi (68167), Sally Baron-Hay (6335351), Yang Liao (292677), David Chisanga (6335348), Caitlin Murphy (6335339)   +12 more
core   +1 more source

A panel of tumor biomarkers to predict complete pathological response to neo-adjuvant treatment in Locally Advanced Rectal Cancer [PDF]

, 2021
Pathological complete response after neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients is related to a favorable prognosis. The identification of early biomarkers predictive of pathological complete response would help to optimize ...
Palazzari, Elisa, Buonadonna, Angela, Dalle Fratte, Chiara, Mezzalira, Silvia, Palumbo, Antonio, De Paoli, Antonino, Canzonieri, Vincenzo, Toffoli, Giuseppe, Cecchin, Erika, De Mattia, Elena, Belluco, Claudio, Polesel, Jerry   +11 more
core   +1 more source

Pathological complete response in younger and older breast cancer patients [PDF]

Archives of Medical Science, 2012
Pathologic complete response (pCR) after neoadjuvant systemic treatment for inoperable locally advanced breast cancer is defined as complete microscopic disappearance of invasive cancer in both the breast and axilla in the postoperative specimen. The aim of the study was to characterize the groups of younger (≤ 40 years old) and older (≥ 70 years old ...
Kołacińska, Agnieszka, Chałubińska, Justyna, Błasińska-Morawiec, Maria, Dowgier-Witczak, Izabela, Fendler, Wojciech, Kordek, Radzisław, Morawiec, Zbigniew   +6 more
openaire   +2 more sources

Impact of Sarcopenia on Treatment Outcomes and Toxicity in Locally Advanced Rectal Cancer

Medicina
Background and Objectives: Sarcopenia, a condition characterized by muscle mass loss, is prevalent in up to 68% of rectal cancer patients and has been described as a negative prognostic factor, impacting overall survival and tumor response.
Sebastian Curcean, Alexandra Gherman, Alexandru Tipcu, Zsolt Fekete, Alina-Simona Muntean, Andra Curcean, Rares Craciun, Stefan Stanciu, Alexandru Irimie   +8 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Gene and microRNA expression predictive of tumour response in patients treated with preoperative chemoradiotherapy for rectal cancer [PDF]

, 2013
Background Preoperative chemoradiotherapy (pCRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). However, the response to pCRT is not uniform, and there is no effective method to predict tumour response to pCRT ...
Maretto, I
core  

An unusual case of complete pathological response to Paget’s disease of the breast

Journal of Surgical Case Reports, 2022
Abstract Mammary Paget’s disease is a rare form of breast cancer present in ~0.5–2.8% of breast cancers. The patients have a poorer prognosis, and usually, the appropriate therapy is based on the pathologic findings of the mass and axillary staging.
Daisy Okonofua, Chien Lin Soh, Habib Tafazal   +2 more
openaire   +2 more sources