Results 221 to 230 of about 1,754,279 (287)

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Targeting peroxynitrite production in a model of persistent temporomandibular disorder comorbid with migraine

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose The persistence of temporomandibular disorders (TMDs), particularly myogenous, in a person with migraine can lead to exacerbated clinical outcomes and limited response to treatment. The pro‐nociceptive reactive nitroxidative species, peroxynitrite, is involved in migraine mechanisms, but little is known of its role in this ...
Simon Akerman   +4 more
wiley   +1 more source

Of hired guns and ideologues: Why would a law firm ever retain an honest expert witness?

open access: yesCanadian Journal of Economics/Revue canadienne d'économique, EarlyView.
Abstract Suppose that expert witnesses appearing in litigation are, generically, either honest in their assessment of a fact situation or are advocates who testify in favour of their retaining party, regardless of new information. The type of a witness is known to law firms, who engage with them repeatedly, but not to courts.
Martin Richardson, Jose Rodrigues‐Neto
wiley   +1 more source

A narrative review of qualitative studies exploring the normalization of gambling for youth and younger adults. [PDF]

open access: yesHealth Promot Int
Murray M   +6 more
europepmc   +1 more source

Adherence to Treatment in Allergic Rhinitis During the Pollen Season in Europe: A MASK‐air Study

open access: yesClinical &Experimental Allergy, Volume 55, Issue 3, Page 226-238, March 2025.
In a study assessing mobile health data, (i) adherence to rhinitis medication was highest for oral antihistamines and lowest for azelastine‐fluticasone, (ii) in weeks of partial adherence, azelastine‐fluticasone was associated with lower levels of reported rhinitis symptoms than other medication classes.
Bernardo Sousa‐Pinto   +121 more
wiley   +1 more source

Accountability and Hyperaccountability in Child Protection Scandals

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT The number of child abuse–related deaths has decreased significantly in the United Kingdom over the past 50 years, but there remains public and political concern about the actual and perceived risk of child deaths, with resultant processes enacted to supervise child protection practice.
Robin Sen, John Devaney
wiley   +1 more source

Outcomes for post‐transplant relapsed acute lymphoblastic leukaemia in the era of novel therapies: A retrospective multicentre UK study

open access: yes
British Journal of Haematology, EarlyView.
Alexandros Rampotas   +16 more
wiley   +1 more source

Home - About - Disclaimer - Privacy