Results 111 to 120 of about 981,501 (315)

Pathogenesis of Inflammation in Skin Disease: From Molecular Mechanisms to Pathology

Many skin diseases begin with inflammatory changes on a molecular level. To develop a more thorough understanding of skin pathology and to identify new targets for therapeutic advancements, molecular mechanisms of inflammation in the context of skin ...
Abigail E. Watson, Simona N. Shirley, Nabiha Yusuf   +2 more
core   +1 more source

Revisiting Oversight and Regulation of Molecular-Based Laboratory-Developed Tests A Position Statement of the Association for Molecular Pathology

, 2014
Since 2006, the US Food and Drug Administration, Congress, and other policymakers have explored the appropriate way to guarantee the clinical and analytical validity of laboratory-developed tests.
Nowak, Jan A., Day, Stephen P., Williams, Mary S., Klein, Roger D., Ferreira-Gonzalez, Andrea, Emmadi, Rajyasree, Pratt, Victoria M., Lyon, Elaine, Leib, Jennifer R., Klees, Robert F.   +9 more
core   +1 more source

The value of cell-free DNA for molecular pathology. [PDF]

, 2018
Over the past decade, advances in molecular biology and genomics techniques have revolutionized the diagnosis and treatment of cancer. The technological advances in tissue profiling have also been applied to the study of cell-free nucleic acids, an area ...
Prachi D Kothari, Caitlin M Stewart, Arcila, Maria E., Weigelt, Britta, Ahmet Zehir, Richard Mair, Kothari, Prachi D., Mouliere, F, Tsui, Dana W.Y., Maria E Arcila, Sarah-Jane Dawson, Mair, Richard, Ryma Benayed, Zehir, A, Zehir, Ahmet, Berger, MF, Stewart, Caitlin M, Dawson, Sarah Jane, Berger, Michael F, Arcila, ME, Dawson, Sarah‐Jane, Tsui, DWY, Dana WY Tsui, Mair, R, Benayed, Ryma, Britta Weigelt, Mouliere, Florent, Tsui, Dana WY, Arcila, Maria E, Kothari, Prachi D, Saira Somnay, Mouliere, Florent; id_orcid, Dawson, SJ, Stewart, Caitlin M., Michael F Berger, Somnay, S, Somnay, Saira, Benayed, R, Florent Mouliere, Stewart, CM, Berger, Michael F., Kothari, PD, Weigelt, B   +42 more
core   +1 more source

Exploring the Molecular Pathology of Iatrogenic Amyloidosis

Journal of Molecular Pathology
Iatrogenic amyloidosis results from medical therapeutic interventions, leading to the misfolding and aggregation of proteins into amyloid fibrils or to their direct deposition in different tissues.
Bernardo Bonilauri
doaj   +1 more source

NTRK Fusions in a Sarcomas Series: Pathology, Molecular and Clinical Aspects. [PDF]

Pathol Oncol Res, 2022
Siozopoulou V, Marcq E, De Winne K, Norga K, Schmitz G, Duwel V, Delvenne P, Smits E, Pauwels P.   +8 more
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain. [PDF]

Proc Natl Acad Sci U S A, 2022
Killinger BA, Marshall LL, Chatterjee D, Chu Y, Bras J, Guerreiro R, Kordower JH.   +6 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Molecular pathology for the general pathologist: Second oration of the Indian college of pathologists

Indian Journal of Pathology and Microbiology, 2010
Molecular diagnostic tools form a necessitity in the modern practice of pathology. This review aims to introduce some basic principles of molecular diagnostics to a pathologist involved in the practice of histology. Some common clinical scenarios and the
Bhusnurmath Shivayogi
doaj