Results 121 to 130 of about 981,501 (315)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Molecular pathology : the molecular basis of human disease /

Includes index.Online resource; title from PDF title page (ScienceDirect, viewed October 10, 2017).Includes bibliographical references and index.Molecular mechanisms of cell death / John J.
Tsongalis, Gregory J.,editor., Coleman, William B.,editor.   +1 more
core  

The application of intraoperative molecular diagnosis in glioma surgery

Chinese Journal of Contemporary Neurology and Neurosurgery
Background Glioma is the most common malignant tumor of the central nervous system, and intraoperative accurate diagnosis is critical for formulating rational surgical strategies.
HAN Zhe, LI Gang, XUE Hao
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Importance of Brain Banks for Molecular Neuropathological Research: The New South Wales Tissue Resource Centre Experience

, 2009
New developments in molecular neuropathology have evoked increased demands for postmortem human brain tissue. The New South Wales Tissue Resource Centre (TRC) at The University of Sydney has grown from a small tissue collection into one of the leading ...
Donna Sheedy, Antony Harding, Clive G. Harper, Clare Hunt, Irina Dedova, Nina Sundqvist, Therese Garrick, Juliette Gillies   +7 more
core   +1 more source

Integrating molecular pathology to endometrial cancer

Taiwanese Journal of Obstetrics & Gynecology, 2023
Yiu-Tai Li, Chiao-Hao Liu, Peng-Hui Wang
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Correlation analysis on epidermal growth factor receptor (EGFR) mutations and clinicopathological characteristics in lung adenocarcinomas

Frontiers in Oncology
PurposeTo analysis the correlation between EGFR mutations and clinicopathological features in lung adenocarcinomas.Methods139 lung adenocarcinoma cases from the Second Hospital of Shandong University were conducted molecular detection of EGFR mutations ...
Haitao Wang, Changhua Ji, Chengjun Zhou, Hui Li   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Opportunities and Challenges Associated with Clinical Diagnostic Genome Sequencing A Report of the Association for Molecular Pathology

, 2012
This report of the Whole Genome Analysis group of the Association for Molecular Pathology illuminates the opportunities and challenges associated with clinical diagnostic genome sequencing.
Gonzalez, Andrea Ferreira, Hambuch, Tina, Leonard, Debra G.B., Klein, Roger D., Farkas, Daniel H., Pratt, Victoria M., Voelkerding, Karl V., Greiner, Timothy C., Grody, Wayne W., Furtado, Manohar, Kalman, Lisa, Sobel, Mark E., Lubin, Ira M., Aziz, Nazneen, Kant, Jeffrey A., Schrijver, Iris, Nagan, Narasimhan, Mao, Rong, Gibson, Jane S.   +18 more
core   +1 more source