Results 231 to 240 of about 981,501 (315)

Spatial transcriptomics in Alzheimer's disease: technologies, challenges and discoveries. [PDF]

Mol Neurodegener Adv
Shi CH, Piña-Crespo JC, Yip KY, Huang TY.   +3 more
europepmc   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Strengthening Biomarker Research in Canadian Cancer Clinical Trials: A Pathology-Focused White Paper. [PDF]

Curr Oncol
Schaeffer DF, Chan J, Morin J, Guiot MC, Yousef GM, Streutker CJ, Sekhon H, Fitzpatrick M, Virk S, Wyatt A, Spatz A, Shepherd L, Loree JM, Kinloch M, CCTG Pathology Working Group.   +14 more
europepmc   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

The SALV-Dataset Registry: An Expertly Curated Digital Clinicopathological Dataset for Salivary Gland Tumor Research and AI-Assisted Diagnostic Tools. [PDF]

Head Neck Pathol
Burghout KST, Weijer JAJ, Evers AC, Breimer GE, van Rossem JN, Peferoen LAN, Bloemena E, Koppes SA, van Dis V, Verdijk RM, van Engen-van Grunsven I, Doeleman T, van den Hout MFCM, van der Vegt B, Doff JJ, Hazelbag HM, Smit LA, de Cuba EMV, Ooft ML, Rupp NJ, Steeghs EMP, de Ridder M, de Bree R, Slingerland M, Smit VTHBM, van Egmond SL, Cohen D.   +26 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Correction to Biosurveillance of Invasive Southern Corn Rust: Insights Into Recent Migration Patterns and Virulence Variation. [PDF]

Mol Plant Pathol
europepmc   +1 more source

Digital pathology and artificial intelligence in breast and gynecologic oncology: from molecular prediction to multimodal integration. [PDF]

Front Oncol
Polit F, Bahmad HF, Kassab MB, Elajami MK, Recine M, Alghamdi S, Poppiti R.   +6 more
europepmc   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

A novel hierarchical framework elucidating regional differences in α-synuclein and tau co-pathology in military veterans with parkinsonism. [PDF]

J Neuropathol Exp Neurol
Flores Almazan VG, Laborc KF, De Sanctis C, Thorn EL, Goldstein A, Cervera A, Quintana Mora DF, Mendez Y, McGoldrick AC, Chiu LY, Hossain QI, McQuillan S, Lind-Watson K, Walker JM, Walker RH, Nirenberg MJ, Crary JF.   +16 more
europepmc   +1 more source