Results 221 to 230 of about 909,959 (268)
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The molecular pathology of cancer
Nature Reviews Clinical Oncology, 2010Rapid technical advances in DNA sequencing and genome-wide association studies are driving the discovery of the germline and somatic mutations that are present in different cancers. Mutations in genes involved in cellular signaling are common, and often shared by tumors that arise in distinct anatomical locations.
Timothy J R, Harris, Frank, McCormick
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Molecular Pathology of Meningiomas
Ideggyógyászati szemle, 2015Meningiomas represent nearly one-third of all adult primary brain tumours. According to their clinical and histologic appearance, they can be divided into WHO grades I-III. Almost 90% of meningiomas are benign, showing favourable response to conventional therapies, however, patients diagnosed with grade 2 and 3 tumours may have a poor prognosis.
Balazs, Murnyák +2 more
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Molecular Pathology Techniques
Clinics in Laboratory Medicine, 2013Molecular pathology techniques have matured considerably over the last decade. New technologies have provided increased sensitivity for improved diagnostic capacity. Furthermore, novel methodologies have matured to interrogate nucleic acid and protein signatures effectively to aid in elucidating the pathophysiology of disease in addition to diagnosis ...
Mark J, Bluth, Martin H, Bluth
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Molecular pathology of urothelial carcinoma
Human Pathology, 2021The current personalized oncology era has witnessed significant efforts to integrate clinical, pathological, and molecular classifications. The growing need for molecular biomarkers to feed personalized oncology, together with the unprecedented wealth of knowledge on the molecular basis of bladder cancer, has led to a novel approach to this disease ...
Antonio Lopez-Beltran +3 more
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Molecular pathology — The future?
The Surgeon, 2009The diagnosis and management of complex disease requires multidisciplinary clinical collaboration. Histopathological assessment of tissues is an important part of this approach and relies on the morphological appraisal of stained tissues by light microscopy. Although considered the 'gold standard', morphology alone is becoming increasingly insufficient
G G A, Hutchins, H I, Grabsch
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Predictive Molecular Pathology
New England Journal of Medicine, 2002The search for markers that can predict the outcome in an individual patient with cancer or the response of an individual tumor to specific therapies is a major focus of cancer research. Despite these efforts, estrogen and progesterone receptors and the HER2/neu gene are the only molecular targets that are analyzed routinely in newly diagnosed breast ...
Sauter G, Simon R
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Pathology and Molecular Pathology of Meningioma
2021Meningiomas are the most common primary brain tumors occurring primarily in elderly adults with a female preponderance. Meningiomas are classified into 15 histopathological subtypes occurring across three WHO grades (1–3). Majority meningiomas are benign grade 1 meningiomas. Up to 25% are of grade 2 histology and rarely are of grade 3 histology.
Aruna Nambirajan +2 more
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Molecular pathology of melanoma
Cancer and Metastasis Reviews, 1997There has long been a clinical need for improved molecular pathology in melanoma, particularly in the histopathology laboratory where the differentiation of melanoma from its benign counterparts is commonly difficult. The need for improved molecular pathology has recently increased as immunotherapeutic options for the treatment of the tumour evolve. It
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Molecular Pathology Informatics
Surgical Pathology Clinics, 2015Molecular informatics (MI) is an evolving discipline that will support the dynamic landscape of molecular pathology and personalized medicine. MI provides a fertile ground for development of clinical solutions to bridge the gap between clinical informatics and bioinformatics.
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Pathology and Molecular Pathology of Ependymoma
2021Ependymomas are relatively rare glial neoplasms that recapitulate the morphological, immunohistochemical, and ultrastructural features of ependymal cells lining the ventricles and central canal of spinal cord. They present in both children and adults and occur across all three anatomical compartments of the central nervous system: supratentorium ...
Aruna Nambirajan +2 more
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