Results 21 to 30 of about 370,051 (261)
Journal of Family Medicine and Primary Care, 2019 Background and Aim: There is a paucity of information about awareness about oral pathology speciality among medical professionals. To the best of my knowledge, this is the first study to be reported in literature.
Thorakkal Shamim
doaj +1 more source
Exploring the chemical space of protein–protein interaction inhibitors through machine learning
Scientific Reports, 2021 Although protein–protein interactions (PPIs) have emerged as the basis of potential new therapeutic approaches, targeting intracellular PPIs with small molecule inhibitors is conventionally considered highly challenging.
Jiwon Choi +5 more
doaj +1 more source
The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo +5 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye +33 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Disrupted tenogenesis in masseter as a potential cause of micrognathia
International Journal of Oral Science, 2022 Micrognathia is a severe craniofacial deformity affecting appearance and survival. Previous studies revealed that multiple factors involved in the osteogenesis of mandibular bone have contributed to micrognathia, but concerned little on factors other ...
Chao Liu +10 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Plasma Cell Mucositis: A Differential Diagnosis–Oriented Case Report
Case Reports in DentistryWe present the case of an 80-year-old woman who reported painful gingival swelling and bleeding gums persisting for 6 months. She had hypertension (treated with amlodipine and losartan), arrhythmia (digoxin), and hypothyroidism (levothyroxine ...
Matías Klare Rojas +4 more
doaj +1 more source
“The Standard Procedure” for Investigation of Oral Neutrophils in Oral Diseases
International Journal of Dentistry, 2023 Aim. There is need of an objective “standard procedure” that is reliable and clinically applicable for estimating oral neutrophil content in relation to oral diseases. Methods.
Peter Østrup Jensen +4 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source