Results 31 to 40 of about 369,599 (261)

Disrupted tenogenesis in masseter as a potential cause of micrognathia

International Journal of Oral Science, 2022
Micrognathia is a severe craniofacial deformity affecting appearance and survival. Previous studies revealed that multiple factors involved in the osteogenesis of mandibular bone have contributed to micrognathia, but concerned little on factors other ...
Chao Liu, Nan Zhou, Nan Li, Tian Xu, Xiaoyan Chen, Hailing Zhou, Ailun Xie, Han Liu, Lei Zhu, Songlin Wang, Jing Xiao   +10 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease

Journal of Immunology Research
Sjögren disease (SjD) is an autoimmune disorder that predominantly affects the exocrine glands, and advancing age is recognized as an important risk factor for its development.
Mari Nishida, Kunihiro Otsuka, Ruka Nagao, Shigefumi Matsuzawa, Aya Ushio, Takaaki Tsunematsu, Keiko Aota, Naozumi Ishimaru   +7 more
doaj   +1 more source

Keratocystoma of palatal minor salivary glands: a case report

Journal of Oral Medicine and Oral Surgery
Keratocystoma is a rare benign tumor of the salivary glands. Initially described as a choristoma by Seifert et al. in 1999, the term “keratocystoma” was later proposed by Nagao et al. in 2001. The parotid gland is the most common site of occurrence. Only
Benaouf Souad, Kraloua Saadia, Larbi Meriem, El Amine Khebichat Moncef, Tabeti-Bentahar Cherifa Faiza   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Clinicopathologic Study of Oral Mucosa-Derived Hamartomas and Choristomas and Literature Review

International Journal of Dentistry
This study aimed to investigate the sociodemographic and clinicopathological data of oral soft tissue hamartomas and choristomas. A cross-sectional study was delineated to quantitatively analyze oral soft tissue hamartomas and choristomas cases diagnosed
Ianca Daniele Oliveira de Jesus, Anaíra Ribeiro Guedes Fonseca Costa, Débora de Oliveira Santos, Sérgio Vitorino Cardoso, Nayara Rúbio Diniz Del Nero, Adriano Mota Loyola, Paulo Rogério de Faria   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

TOPICAL CORTICOSTEROIDS IN ORAL PATHOLOGY [PDF]

Journal of IMAB, 2010
Topical corticosteroids have been commonly used over the last 50 years to treat various inflammatory mucosal conditions. The wide spectrum of potencies and bases allows these medications to be used effectively and safely under the care of an experienced ...
Adriana Krasteva, Assya Krasteva, Angelina Kisselova-Yaneva   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source