Results 231 to 240 of about 3,834,924 (331)

Using the Scoring Hip Osteoarthritis with Magnetic Resonance Imaging (SHOMRI) system to assess intra‐articular pathology in femoroacetabular impingement [PDF]

, 2018
Trevor R. Grace, Jan Neumann, Michael A. Samaan, Richard B. Souza, Sharmila Majumdar, Thomas M. Link, Alan L. Zhang   +6 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Tau pathology in the brainstem monoaminergic neurons reflect resilience to Alzheimer's disease pathology in the Nun study cases. [PDF]

Acta Neuropathol Commun
Pezhouh MK, Chen G, Meints J, Hemmy LS, SantaCruz KS, Lee MK.   +5 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Reframing TDP-43 in Alzheimer's disease: From co-pathology to neurovascular culprit. [PDF]

Alzheimers Dement
Di Donna MG, Motta C, Bonomi CG, Bernocchi F, Ricci F, Poli M, Koch G, Martorana A.   +7 more
europepmc   +1 more source

Clear cell lesions in pathology: Histomorphologic approach to diagnosis

, 2020
Asaranti Kar, Kaumudee Pattnaik, Tushar Kar, Priyadarshini Biswal, Chandraprava Mishra, Lilabati Guru   +5 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Generative artificial intelligence as an aid in interpreting thyroid FNA cytopathological images: Are we there yet? [PDF]

Cancer Cytopathol
Saieg M, Lago PP, Pusztaszeri MP.
europepmc   +1 more source

Contribution of Alzheimer's disease neuropathologic change to the cognitive dysfunction in human brains with Lewy body–related pathology

, 2020
Wanying Zhang, Qing Zhang, Qian Yang, Pan Liu, Tianyi Sun, Yuanyuan Xu, Xiaojing Qian, Wenying Qiu, Chao Ma   +8 more
openalex   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source