Results 131 to 140 of about 1,906,254 (260)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics

Neuropsychiatric Disease and Treatment
Dingyue Chai,1 Yuzi Sun,1 Jiamin Lu,1 Yuhui Yao,2 Chunyu Jiang,1 Lihui Wu,1 Qianqian Cai3 1Departments of Basic Medicine and Forensic Medicine, Hangzhou Medical College, Hangzhou, People’s Republic of China; 2Department of Paediatrics, The First Hospital
Chai D, Sun Y, Lu J, Yao Y, Jiang C, Wu L, Cai Q   +6 more
doaj  

Implicit leadership and multidimensional imitation: a structural pathway model among Chinese university students. [PDF]

Front Psychol
Zhang J, Wang Q, Zhou S, Zhai L, Fang Z, Rhee GS.   +5 more
europepmc   +1 more source

Homology directed correction, a new pathway model for point mutation repair catalyzed by CRISPR-Cas. [PDF]

Sci Rep, 2022
Sansbury BM, Hewes AM, Tharp OM, Masciarelli SB, Kaouser S, Kmiec EB.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Toward a dual-pathway model of neuroplastic adaptation in sport: neural efficiency and neural optimization. [PDF]

Front Neurosci
Sultanov M, Rustamova T, Huseynova A, Mammadova G, Ismailova K.   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

How Employees' Emotional Labor Promotes Perceived Service Quality: A Dual-Pathway Model. [PDF]

Behav Sci (Basel)
Cheng P, Zhao X.
europepmc   +1 more source

Childhood adversity predicts black young adults' DNA methylation-based accelerated aging: A dual pathway model. [PDF]

Dev Psychopathol, 2022
Beach SRH, Gibbons FX, Carter SE, Ong ML, Lavner JA, Lei MK, Simons RL, Gerrard M, Philibert RA.   +8 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source