Results 131 to 140 of about 1,910,959 (261)

Homology directed correction, a new pathway model for point mutation repair catalyzed by CRISPR-Cas. [PDF]

open access: yesSci Rep, 2022
Sansbury BM   +5 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics

open access: yesNeuropsychiatric Disease and Treatment
Dingyue Chai,1 Yuzi Sun,1 Jiamin Lu,1 Yuhui Yao,2 Chunyu Jiang,1 Lihui Wu,1 Qianqian Cai3 1Departments of Basic Medicine and Forensic Medicine, Hangzhou Medical College, Hangzhou, People’s Republic of China; 2Department of Paediatrics, The First Hospital
Chai D   +6 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Childhood adversity predicts black young adults' DNA methylation-based accelerated aging: A dual pathway model. [PDF]

open access: yesDev Psychopathol, 2022
Beach SRH   +8 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Sustainable Entrepreneurship Emergence as Practice: A Multi-Level Pathway Model. [PDF]

open access: yesF1000Res
Pardede G   +6 more
europepmc   +1 more source

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