Results 171 to 180 of about 3,311,692 (342)

Update from the laboratory: mechanistic studies of pathways of cancer-associated venous thrombosis using mouse models [PDF]

, 2019
Yohei Hisada, Nigel Mackman
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Childhood adversity predicts black young adults' DNA methylation-based accelerated aging: A dual pathway model. [PDF]

Dev Psychopathol, 2022
Beach SRH, Gibbons FX, Carter SE, Ong ML, Lavner JA, Lei MK, Simons RL, Gerrard M, Philibert RA.   +8 more
europepmc   +1 more source

MOESM6 of RNA-Seq transcriptomic analysis with Bag2D software identifies key pathways enhancing lipid yield in a high lipid-producing mutant of the non-model green alga Dunaliella tertiolecta

, 2015
Lina Yao, Tin Wee Tan, Yi-Kai Ng, Kenneth Ban, Hui Shen, Huixin Lin, Yuan Chuan Lee   +6 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics

Neuropsychiatric Disease and Treatment
Dingyue Chai,1 Yuzi Sun,1 Jiamin Lu,1 Yuhui Yao,2 Chunyu Jiang,1 Lihui Wu,1 Qianqian Cai3 1Departments of Basic Medicine and Forensic Medicine, Hangzhou Medical College, Hangzhou, People’s Republic of China; 2Department of Paediatrics, The First Hospital
Chai D, Sun Y, Lu J, Yao Y, Jiang C, Wu L, Cai Q   +6 more
doaj  

Towards a Parsimonious Pathway Model of Modifiable and Mediating Risk Factors Leading to Diabetes Risk. [PDF]

Int J Environ Res Public Health, 2021
Ho YL, Lee VSY, Ho MR, Lin GJ, Thumboo J.   +4 more
europepmc   +1 more source

Additional file 2: of Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models

, 2015
Jacob B. Hall, Jessica N. Cooke Bailey, Joshua Hoffman, Margaret A. Pericak‐Vance, William K. Scott, Jaclyn L. Kovach, Stephen G. Schwartz, Anita Agarwal, Milam A. Brantley, Jonathan L. Haines, William S. Bush   +10 more
openalex   +1 more source

Developing discriminate model and comparative analysis of differentially expressed genes and pathways for bloodstream samples of diabetes mellitus type 2 [PDF]

, 2014
Chang Liu, Lili Lu, Quan Kong, Yan Li, Haihua Wu, William Yang, XU Shan-dan, Xinyu Yang, Xiaolei Song, Jack Yang, Mary Qu Yang, Youping Deng   +11 more
openalex   +1 more source