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Pathway modeling

2011
Biological pathways represent a critical level of biological organization and understanding of biochemical pathways is identified as key to future advances in biological sciences (Schaefer, 2004). The overall goal of this thesis is to develop a pathway based approach that integrates different aspects of biological pathways, specifically the structure ...
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Models of cell signaling pathways

Current Opinion in Genetics & Development, 2004
Cellular signaling circuits handle an enormous range of computations. Beyond the housekeeping, replicating and other functions of individual cells, signaling circuits must implement the immensely complex logic of development and function of multicellular organisms. Computer models are useful tools to understand this complexity.
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Modeling signaling pathways in articular cartilage

2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011
Chondrocytes, the only cell type in articular cartilage, are responsible for maintaining the composition of cartilage extracellular matrix (ECM) through a complex interplay of anabolic and catabolic stimuli. Although understanding the way chondrocytes respond to stimuli is of utmost importance for shedding light into the etiology of joint diseases, an ...
Ioannis N, Melas   +5 more
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Introducing the Pathways Model

2013
The demographics and etiologies of illness have changed in the past ­century. The most common causes of mortality and morbidity today are diseases of lifestyle, behavior, and adaptation; stress-related conditions; chronic illnesses and impairments; and complex biopsychosocial conditions.
Angele McGrady, Donald Moss
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Dynamic pathway modeling of sphingolipid metabolism

The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005
We report our research results on computational metabolome study. The goal of this research is to extend the integrated experimental modeling methodologies in sphingolipid metabolism study to other complex biological process studies such as signal transduction or gene regulation.
Peter A, Henning   +2 more
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Pathway Modeling and Simulation

2009
In this chapter we will combine the modeling methods described in Chapter 4 to model and simulate larger pathways. Specifically, we will create models for the gene regulatory, metabolic, and signaling pathways using Cell Illustrator. This chapter should enable the reader to create a variety of new pathways.
Masao Nagasaki   +4 more
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Modeling Protein Folding Pathways

2008
Proteins fold through a series of intermediate states called a pathway. Protein folding pathways have been modeled using either simulations or a heirarchy of statistical models. Here we present a series of related statistical models that attempt to predict early, middle and late intermediates along the folding pathway. Isites motifs are discrete models
Christopher Bystroff, Yu Shao
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Mathematical modeling of metabolic pathways

2008
Bir metabolik patway’in kinetik analizini yapmak için, onun kinetik analizini tanımlayan matematiksel modelini inşa etmek en önemli olaydır. Bir metabolik teoride, iX metabolitinin ix konsantrasyonundaki değişimin hızı, sistemde bulunan ve her biri iX metabolitinin stokiyometri katsayısına göre ağırlıklı tane reaksiyonun hızlarının toplamı olarak kabul
Bayram, Mustafa, Serim, Burcu Özyurt
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A SUICIDE PATHWAYS MODEL

2010
In this chapter, the medical, sociological and medicalization models are drawn together. Stressors (predicaments) have an impact on vulnerable individuals. Vulnerability takes two forms, one from the sociological perspective (due to the regulations and support provided by society) and the other from the medical perspective (due to nature and nurture ...
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Pathway Models

2017
A. M. Mathai, H. J. Haubold
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