Results 71 to 80 of about 3,311,692 (342)

Stronger computational modelling of signalling pathways using both continuous and discrete-state methods [PDF]

, 2006
Starting from a biochemical signalling pathway model expresses in a process algebra enriched with quantitative information, we automatically derive both continuous-space and discrete-space representations suitable for numerical evaluation.
A. Aziz, A. Chatterjee, B. Schoeberl, C. Priami, D. Gillespie, D.T. Gillespie, D.T. Gillespie, F.H. Chi-Ying, J. Hillston, J. Hillston, J. Hillston, K.-H. Cho, L.F. Shampine, M. Buchholtz, M. Kwiatkowska, M. Rathinam, O. Wolkenhauer, S. Ramsey, T.E. Turner, Y. Cao   +19 more
core   +5 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Robustness of Nutrient Signaling Is Maintained by Interconnectivity Between Signal Transduction Pathways

Frontiers in Physiology, 2019
Systems biology approaches provide means to study the interplay between biological processes leading to the mechanistic understanding of the properties of complex biological systems.
Niek Welkenhuysen, Niek Welkenhuysen, Barbara Schnitzer, Barbara Schnitzer, Linnea Österberg, Linnea Österberg, Linnea Österberg, Marija Cvijovic, Marija Cvijovic   +8 more
doaj   +1 more source

Identification of Pathway-Specific Protein Domain by Incorporating Hyperparameter Optimization Based on 2D Convolutional Neural Network

IEEE Access, 2020
Pathway-specific protein domain (PSPD) are associated with specific pathways. Many protein domains are pervasive in various biological processes, whereas other domains are linked to specific pathways.
Ali Ghualm, Xiujuan Lei, Yuchen Zhang, Shi Cheng, Min Guo   +4 more
doaj   +1 more source

A Pathway Idea for Model Building [PDF]

Journal of Statistics Applications & Probability, 2012
Models, mathematical or stochastic, which move from one functional form to another through pathway parameters, so that in between stages can be captured, are examined in this article. Models which move from generalized type-1 beta family to type-2 beta family, to generalized gamma family to generalized Mittag-Leffler family to Lévy distributions are ...
A M, Mathai, Panagis, Moschopoulos
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Pathway to Fractional Integrals, Fractional Differential Equations, and Role of the H-Function

Axioms
In this paper, the pathway model for the real scalar variable case is re-explored and its connections to fractional integrals, solutions of fractional differential equations, Tsallis statistics and superstatistics in statistical mechanics, the reaction ...
Arak M. Mathai, Hans J. Haubold
doaj   +1 more source