Results 41 to 50 of about 449,698 (268)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Commodity risk assessment of Lonicera ligustrina var. pileata, Lonicera ligustrina var. yunnanensis and Lonicera periclymenum plants from the UK

EFSA Journal
The European Commission requested the EFSA Panel on Plant Health to prepare and deliver risk assessments for commodities listed in Commission Implementing Regulation (EU) 2018/2019 as ‘High risk plants, plant products and other objects’.
EFSA Panel on Plant Health (PLH), Antonio Vicent Civera, Paula Baptista, Anna Berlin, Elisavet Chatzivassiliou, Jaime Cubero, Nik Cunniffe, Eduardo de laPeña, Nicolas Desneux, Francesco Di Serio, Anna Filipiak, Paolo Gonthier, Beata Hasiów‐Jaroszewska, Hervé Jactel, Blanca B. Landa, Lara Maistrello, David Makowski, Panagiotis Milonas, Nikos T. Papadopoulos, Hanna Susi, Dirk Jan van derGaag, Jane Debode, Juan A. Navas‐Cortes, Christos Kritikos, Maria Kormpi, Dimitrios Papachristos, Chrysavgi Reppa, Antigoni Akrivou, Spyridon Antonatos, Despoina Beris, Olaf Mosbach Schulz, Monia Federica Lombardo, Ciro Gardi, Roel Potting   +33 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Commodity risk assessment of Vitis spp. plants from Moldova

EFSA Journal
The European Commission requests EFSA to provide scientific opinions in the field of plant health in accordance with Article 29 of Regulation (EC) No 178/2002. Annex VI of Commission Implementing Regulation (EU) 2019/2072 lists plants, plant products and
EFSA Panel on Plant Health (PLH), Antonio Vicent Civera, Paula Baptista, Elisavet Chatzivassiliou, Jaime Cubero, Nik Cunniffe, Eduardo de laPeña, Nicolas Desneux, Anna Filipiak, Paolo Gonthier, Beata Hasiów‐Jaroszewska, Hervé Jactel, Blanca B. Landa, Lara Maistrello, David Makowski, Panagiotis Milonas, Nikos T. Papadopoulos, Roel Potting, Hanna Susi, Dirk Jan van derGaag, Pedro Gómez, Annemarie Fejer Justesen, Andrea Lucchi, Gregor Urek, Jonathan Yuen, Lucia Zappala, Umberto Bernardo, Giovanni Bubici, Anna Vittoria Carluccio, Michela Chiumenti, Francesco Di Serio, Elena Fanelli, Paraskevi Kariampa, Cristina Marzachì, Agata Kaczmarek, Louise Matic, Olaf Mosbach‐Schulz, Anna Berlin   +37 more
doaj   +1 more source

Pest risk assessment of Spodoptera frugiperda for the European Union

EFSA Journal, 2018
EFSA was asked for a partial risk assessment of Spodoptera frugiperda for the territory of the EU focussing on the main pathways for entry, factors affecting establishment, risk reduction options and pest management. As a polyphagous pest, five commodity
EFSA Panel on Plant Health (EFSA PLH Panel), Michael Jeger, Claude Bragard, David Caffier, Thierry Candresse, Elisavet Chatzivassiliou, Katharina Dehnen‐Schmutz, Gianni Gilioli, Jean‐Claude Grégoire, Josep Anton Jaques Miret, Maria Navajas Navarro, Björn Niere, Stephen Parnell, Roel Potting, Trond Rafoss, Vittorio Rossi, Gregor Urek, Ariena Van Bruggen, Wopke Van der Werf, Jonathan West, Stephan Winter, Roger Day, Regan Early, Allan Hruska, Rodney Nagoshi, Ciro Gardi, Olaf Mosbach‐Schultz, Alan MacLeod   +27 more
doaj   +1 more source

Implementing the right care in the right place at the right time for non-alcoholic fatty liver disease (NAFLD-RRR study): a study protocol for a community care pathway for people with type 2 diabetes

BMC Health Services Research, 2022
Background Non-alcoholic fatty liver disease (NAFLD) is an emerging epidemic that affects approximately half of all people with type 2 diabetes. Those with type 2 diabetes are a high-risk NAFLD subgroup because of their increased risk of clinically ...
Lucy Gracen, Kelly L. Hayward, Melanie Aikebuse, Anthony Russell, James O’Beirne, Steven McPhail, Katharine M. Irvine, Suzanne Williams, Patricia C. Valery, Elizabeth E. Powell   +9 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Commodity risk assessment of Prunus spinosa plants from United Kingdom

EFSA Journal
The European Commission requested the EFSA Panel on Plant Health to prepare and deliver risk assessments for commodities listed in Commission Implementing Regulation (EU) 2018/2019 as ‘High risk plants, plant products and other objects’.
EFSA Panel on Plant Health (PLH), Claude Bragard, Paula Baptista, Elisavet Chatzivassiliou, Paolo Gonthier, Josep Anton Jaques Miret, Annemarie Fejer Justesen, Alan MacLeod, Christer Sven Magnusson, Panagiotis Milonas, Juan A. Navas‐Cortes, Stephen Parnell, Roel Potting, Philippe Lucien Reignault, Emilio Stefani, Hans‐Hermann Thulke, Wopke Van der Werf, Antonio Vicent Civera, Lucia Zappalà, Andrea Lucchi, Pedro Gómez, Gregor Urek, Umberto Bernardo, Giovanni Bubici, Anna Vittoria Carluccio, Michela Chiumenti, Francesco Di Serio, Elena Fanelli, Paraskevi Kariampa Cristina Marzachì, Cristiana Do Vale Correia, Olaf Mosbach‐Schulz, Agata Kaczmarek, Jonathan Yuen   +32 more
doaj   +1 more source

Assessment of risk based on variant pathways and establishment of an artificial neural network model of thyroid cancer

BMC Medical Genetics, 2019
Background This study aimed to establish an artificial neural network (ANN) model based on variant pathways to predict the risk of thyroid cancer. Methods The RNASeq data of 482 thyroid cancer samples were downloaded from the TCGA database.
Yinlong Zhao, Lingzhi Zhao, Tiezhu Mao, Lili Zhong   +3 more
doaj   +1 more source