Results 91 to 100 of about 7,950,605 (408)
Understanding MAPK Signaling Pathways in Apoptosis
International Journal of Molecular Sciences, 2020 MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or ...
Jicheng Yue, José M. López
semanticscholar +1 more source
Functional Integration of Ecological Networks through Pathway Proliferation [PDF]
Journal of Theoretical Biology 245: 98-111, 2006 Large-scale structural patterns commonly occur in network models of complex systems including a skewed node degree distribution and small-world topology. These patterns suggest common organizational constraints and similar functional consequences. Here, we investigate a structural pattern termed pathway proliferation.
arxiv +1 more source
Journal of Lipid Research, 2009 The nuclear receptor constitutive androstane receptor (CAR) (NR1I3) regulates hepatic genes involved in xenobiotic detoxification as well as genes involved in energy homeostasis.
Jodi M. Maglich +2 more
doaj
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Finding Transition Pathways on Manifolds [PDF]
, 2014 We consider noise-induced transition paths in randomly perturbed dynami- cal systems on a smooth manifold. The classical Freidlin-Wentzell large devia- tion theory in Euclidean spaces is generalized and new forms of action functionals are derived in the ...
Li, Tiejun, Li, Xiaoguang, Zhou, Xiang
core
Pathways in Two-State Protein Folding [PDF]
, 1999 The thermodynamics of proteins indicate that folding/unfolding takes place either through stable intermediates or through a two-state process without intermediates.
Alberts +23 more
core +3 more sources
American Journal of Clinical Oncology, 2016 The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) immune checkpoints are negative regulators of T-cell immune function.
E. Buchbinder, Anupam M. Desai
semanticscholar +1 more source
Predicting pathways for old and new metabolites through clustering [PDF]
arXiv, 2022 The diverse metabolic pathways are fundamental to all living organisms, as they harvest energy, synthesize biomass components, produce molecules to interact with the microenvironment, and neutralize toxins. While discovery of new metabolites and pathways continues, the prediction of pathways for new metabolites can be challenging.
arxiv
Modelling and Analysis of Biochemical Signalling Pathway Cross-talk [PDF]
EPTCS 19, 2010, pp. 40-54, 2010 Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical in producing the correct signal-response relationship.
arxiv +1 more source
BiomedicinesFixed appliance (FA) therapy predisposes patients to white spot lesions (WSLs). The F-ACP complex (amorphous calcium phosphate nanoparticles enriched with carbonate and fluorine and coated with citrate) has been effective for in vitro enamel ...
Massimiliano Ciribè +7 more
doaj +1 more source