Results 91 to 100 of about 5,642,885 (289)

Integrated Rheumatology-Gastroenterology Clinic: An Innovative Organisation for Patients with Multiple Autoimmune Diseases

International Journal of Integrated Care
Introduction: Patients with multiple autoimmune diseases lack continuity of care due to increasing specialisation and siloed practice in healthcare. Despite improvements in quality, this organisation has led to fragmented patient pathways, as related ...
Sarah Holm Junge Jensen, Michal Frumer, Eileen Dorte Shanti Connelly, Rene Østgård, Henning Glerup, Kate Denby, Anja Leth Egsgaard, Charlotte Weiling Appel   +7 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Perceived treatment burden and health-related quality of life in association with healthcare utilisation among patients attending multiple outpatient clinics

Health and Quality of Life Outcomes
Introduction Patients with multimorbidity who frequently require healthcare may experience a higher treatment burden. In this study, we investigated whether high perceived treatment burden and low perceived health-related quality of life (HRQoL) were ...
Cathrine Bell, Charlotte Weiling Appel, Asger Roer Pedersen, Peter Vedsted   +3 more
doaj   +1 more source

Leveraging capacity for transformative sustainability science: a theory of change from the Future Earth Pathways Initiative

Global Sustainability
Non-technical summary To address increasingly pressing social–environmental challenges, the transformative strand of sustainability science seeks to move beyond a descriptive-analytical stance in order to explore and contribute to the implementation of ...
Gilles Marciniak, Davnah Urbach, Flurina Schneider, Cornelia Krug, Ariane de Bremond, Mark Stafford-Smith, Odirilwe Selomane, Rebecca Fenn, Natalie Chong, Sandrine Paillard   +9 more
doaj   +1 more source

An evaluation of DNA-damage response and cell-cycle pathways for breast cancer classification [PDF]

, 2014
Accurate subtyping or classification of breast cancer is important for ensuring proper treatment of patients and also for understanding the molecular mechanisms driving this disease.
Fard, Atefeh Taherian, Ragan, Mark A., Srihari, Sriganesh   +2 more
core   +5 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pathways to Success for Michigan's Opportunity Youth [PDF]

, 2015
Each young person must navigate his/her own pathway into and through postsecondary education and the workforce to long-term success personalized to his/her own unique needs and desires.

core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Calcium Deficiency Rickets in African Adolescents: Cortical Bone Histomorphometry

JBMR Plus, 2019
Rickets due to dietary calcium deficiency has been well described in black African children, but less is known about this condition in black adolescents. We investigated 26 black adolescents (19 males aged 11 to 19 years and 7 females aged 12 to 15 years)
Christine M Schnitzler, John M Pettifor
doaj   +1 more source

Communities in Action: Pathways to Health Equity [PDF]

, 2017
In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in ...

core