Results 101 to 110 of about 7,950,605 (408)
Scientific Reports, 2023 There is a pressing need for global health preventions to curb the escalating burden of non-communicable diseases (NCDs). Utilising multi-country study designs can improve our understanding of how socio-economic context shapes the aetiology of NCDs, and ...
Asanda Mtintsilana +4 more
doaj +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Semiparametric Mixed Model for Evaluating Pathway-Environment Interaction [PDF]
arXiv, 2012 A biological pathway represents a set of genes that serves a particular cellular or a physiological function. The genes within the same pathway are expected to function together and hence may interact with each other. It is also known that many genes, and so pathways, interact with other environmental variables.
arxiv
The South African Journal of Clinical NutritionObjectives: This study examined the potential mediating effect of breastfeeding self-efficacy on the relationship between maternal food insecurity and breastfeeding status.Design: A community-based, cross-sectional study was conducted.Subjects and ...
Claire Hart +4 more
doaj +1 more source
Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19
Antioxidants, 2020 Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a wide array of genes involved in immunity and inflammation, including antiviral actions.
Joe M. McCord +4 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Competitive pathways for peptide deamidation [PDF]
, 2011 Asparagine (Asn) residues spontaneously – yet non-enzymatically – deamidate to form aspartate under physiological conditions, causing time-dependent changes in the conformation of proteins, limiting their lifetime [1]. The 'molecular clocks' hypothesis [
Bulo, RE +4 more
core
(Per)chlorate-reducing bacteria can utilize aerobic and anaerobic pathways of aromatic degradation with (per)chlorate as an electron acceptor. [PDF]
, 2015 UnlabelledThe pathways involved in aromatic compound oxidation under perchlorate and chlorate [collectively known as (per)chlorate]-reducing conditions are poorly understood.
Bauer, Stefan +7 more
core +3 more sources
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways
Cancers, 2017 The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer, glioblastoma, head and neck cancer, pancreatic cancer, and breast ...
Ping Wee, Zhixiang Wang
semanticscholar +1 more source
Finding dominant transition pathways via global optimization of action [PDF]
, 2016 We present a new computational approach, Action-CSA, to sample multiple reaction pathways with fixed initial and final states through global optimization of the Onsager-Machlup action using the conformational space annealing method. This approach successfully samples not only the most dominant pathway but also many other possible paths without initial ...
arxiv +1 more source